CDC24 Antibody

1. Biochemical analysis confirmed that this mutation disturbs the interaction with Bem1 but not the fold of the protein. The larger dataset obtained by NGS achieved a more complete representation of the bipartite interaction interface of Cdc24. PMID: 27402358
2. We propose that the NH2-terminal region unmasks the DH and PB1 domains, leading to the activation of Cdc42 and interaction with Bem1, respectively, to initiate cell polarization PMID: 22117027
3. there are distinct membrane targeting and anchoring domains which function in the localization of the S. cerevisiae Cdc24p guanine nucleotide exchange factor PMID: 14872283
4. Gbetagamma not only targets Far1p to the correct site but may also trigger a conformational change in Far1p that is required for its ability to activate Cdc24p in vivo PMID: 14988725
5. two-step molecular mechanism for the site-specific activation of Cdc24p, which involves Rsr1p/Bud1p and the adaptor protein Bem1p PMID: 14988726
6. Results indicate that the exchange factor Cdc24p is necessary for maintaining or restricting specific proteins required for cell fusion to the cell contact region during mating. PMID: 15302837
7. Cdc24 regulates nuclear shuttling and recruitment of the Ste5 scaffold to a heterotrimeric G protein in Saccharomyces cerevisiae PMID: 15657049
8. The structure of an N-terminally truncated version of the Sc CDC24p PB1 domain was presented. PMID: 15961083
9. study presents the tertiary structure of the heterodimer of Bem1 and Cdc24 PB1 domains determined by NMR spectroscopy PMID: 19451149
10. These data support roles for Boi2p, Ent2p, Hua1p, Tos2p, and for Cdc24p phosphorylation in targeting Cdc24p to growth sites. PMID: 19782078

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KEGG: sce:YAL041W

STRING: 4932.YAL041W