cdc-42 Antibody

Code CSB-PA553764XA01CXY
Size Enquire
Have Questions? Leave a Message or Start an on-line Chat

Product Details

Full Product Name
Rabbit anti-Caenorhabditis elegans cdc-42 Polyclonal antibody
Uniprot No.
Target Names
cdc-42
Alternative Names
cdc-42 antibody; R07G3.1Cell division control protein 42 homolog antibody; CDC42Ce antibody
Raised in
Rabbit
Species Reactivity
Caenorhabditis elegans
Immunogen
Recombinant Caenorhabditis elegans cdc-42 protein
Immunogen Species
Caenorhabditis elegans
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

Customer Reviews and Q&A

 Customer Reviews

There are currently no reviews for this product.

Submit a Review here

Target Background

Function
Plays an essential role in spindle orientation and organizing cellular and embryonic polarity by controlling the localization and activity of PAR (partitioning-defective) proteins. Required for maintaining the asymmetric cortical localization of the anterior complex proteins par-3 and par-6, the posterior cortical protein par-2, and pkc-3. Involved in hypodermal cell fusion, together with pak-1 and ced-10, leading to embryonic body elongation, which involves dramatic cytoskeletal reorganization. During gonad morphogenesis, plays a role in distal tip cell (DTC)-mediated guidance of gonad elongation, probably by activating max-2. May play a role in controlling canal length and in maintaining Golgi and ER stability during excretory canal elongation, probably downstream of ccm-3, which may regulate its activity and expression levels. May play a role in yolk protein clatherin-mediated endocytosis by oocytes during oogenesis. Involved in toca-1 and toca-2-mediated protein trafficking controlling the recycling of endocytic cargo protein mig-14 to the Golgi apparatus. Plays a role in male tail tip morphogenesis. Together with kpc-1 and chin-1, plays a role in guiding axons from neurons, including AIY interneurons, into the nerve ring.
Gene References into Functions
  1. Repression of CDC-42 or SID-3 suppressed trafficking process that requires actin assembly and disassembly. PMID: 29608564
  2. MRCK-1 is required for activation of contractile actomyosin dynamics and elevated cortical tension in the apical cell cortex of endoderm precursor cells. MRCK-1 is apically localized by active Cdc42 at the external, cell-cell contact-free surfaces of apically constricting cells, downstream of cell fate determination mechanisms. PMID: 27451898
  3. Junctional CDC-42 controls actin organization and adherens junction protein levels during epithelial morphogenesis. PMID: 28903999
  4. RGA-7 is recruited to spatially distinct locations at junctions between adjacent leading cells, where it promotes the accumulation of clusters of activated CDC-42. PMID: 26578656
  5. PAR-3 exists in a dynamic equilibrium between an unclustered form and a clustered form, in response to cortical tension mainly exerted by actomyosin contractility. Cortical forces and CDC-42 control clustering of PAR proteins for Caenorhabditis elegans embryonic polarization. PMID: 28737772
  6. UIG-1, a DH/PH domain containing protein, links a PAT-3/UNC-112 complex to the CDC-42 signaling pathway during muscle formation. PMID: 16055082
  7. CDC-42 is required for the invasive membrane localization of WSP-1 (N-WASP), a CDC-42 effector that promotes polymerization of F-actin. Loss of CDC-42 or WSP-1 resulted in fewer invadopodia and delayed BM breaching PMID: 26765257
  8. Multiple cytoskeletal pathways and PI3K signaling mediate CDC-42-induced neuronal protrusion in C. elegans PMID: 24149939
  9. our results suggest that the small GTPase CDC-42 regulates apoptotic cell engulfment possibly upstream of the canonical Rac GTPase CED-10, by polarizing the engulfing cell toward the apoptotic corpse in response to integrin signaling PMID: 24632947
  10. Study propose that radial polarization results from a competition between RhoGEFs, which activate CDC-42 throughout the cortex, and the RhoGAP PAC-1, which inactivates CDC-42 at cell contacts. PMID: 23424200
  11. Mis-regulation of CDC-42 results in increased amounts of PAR-6 in the early embryo. PMID: 23536568
  12. Our data suggest that PAT-2 functions through UIG-1 for CDC-42 activation, which in turn leads to cytoskeletal rearrangement and apoptotic cell internalization by muscle cells. PMID: 22615577
  13. Data show that cdc-42 has the genetic properties consistent with negative regulation of lin-12 activity during vulval precursor cell fate specification. PMID: 20686701
  14. A genetic screen identified one positive (putative guanine nucleotide exchange factor [GEF]) and one negative (putative GTPase activating protein [GAP]) regulator of CDC-42 activity: CGEF-1 and CHIN-1. PMID: 19923324
  15. Results show that CDC-42 is required to remove PAR-2 from the cortex at the end of meiosis and to localize PAR-6 to the cortex. PMID: 16899536
  16. CDC-42 and the PAR-3/PAR-6/aPKC complex act together in a rnage of cell types for polarised cell growth, cell migrations, and cell positioning. PMID: 17383625
  17. A RAC/CDC-42-independent GIT/PIX/PAK signaling pathway mediates cell migration in C. elegans PMID: 19023419

Show More

Hide All

Subcellular Location
Cell membrane; Lipid-anchor; Cytoplasmic side. Recycling endosome. Cytoplasm.
Protein Families
Small GTPase superfamily, Rho family, CDC42 subfamily
Tissue Specificity
Expressed in the intestine and seam cells.
Database Links

KEGG: cel:CELE_R07G3.1

STRING: 6239.R07G3.1.2

UniGene: Cel.34286

icon of phone
Call us
301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
icon of address
Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
icon of social media
Join us with

Subscribe newsletter

Leave a message

* To protect against spam, please pass the CAPTCHA test below.
CAPTCHA verification
© 2007-2024 CUSABIO TECHNOLOGY LLC All rights reserved. 鄂ICP备15011166号-1