CDC6 Antibody

Datasheet

Code	CSB-PA362593XA01SVG
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Target Background

Product Details

Full Product Name

Rabbit anti-Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) CDC6 Polyclonal antibody

Uniprot No.

P09119

Target Names

CDC6

Alternative Names

CDC6 antibody; YJL194W antibody; J0347Cell division control protein 6 antibody

Raised in

Rabbit

Species Reactivity

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Immunogen

Recombinant Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) CDC6 protein

Immunogen Species

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function

Plays a crucial role in forming the pre-replicative complexes. Interacts with the origin recognition complex (ORC) and MCM2-7 helicase complex leading to the linking of those complexes and loading of the replicative helicase MCM2-7 onto the pre-replicative complexes. Required for the initiation of DNA replication and then actively participates in the suppression of nuclear division.

Gene References into Functions

Cdc6 degradation triggered by Mck1 kinase was enhanced upon DNA damage. PMID: 25995377
Cdc6 ATP hydrolysis is therefore required for Cdc6 disengagement from the pre-replicative complex after helicase loading to advance subsequent steps in helicase activation in vivo. PMID: 26305410
We propose that both CDK and Mck1 kinases are required for Cdc6 degradation to ensure a tight control of DNA replication. PMID: 23236290
the mitotic CDK, Clb2/Cdc28, binds tightly to an amino-terminal domain of Cdc6, and Cdc6 in this complex is unable to assemble pre-replicative complexes PMID: 15496876
Cdc6 and origin DNA activate a molecular switch in Origin Recognition Complex that contributes to pre-RC assembly. PMID: 16228006
findings show that Mcm2-7 loading requires the coordinate action of the origin recognition complex and Cdc6 ATPases PMID: 16387651
Cdc6 protein is crucial for DNA replication PMID: 17267692
Cdc6 ATPase activity regulates ORC x Cdc6 stability and the selection of specific DNA sequences as origins of DNA replication PMID: 17314092

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Subcellular Location

Nucleus. Chromosome.

Protein Families

CDC6/cdc18 family

Database Links

KEGG: sce:YJL194W

STRING: 4932.YJL194W

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Email: [email protected]
Distributors Worldwide

Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

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Related pathways

Cell cycle

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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CDC6 Antibody

Product Details

Related Products

Customer Reviews and Q&A

Target Background