CDK8 Antibody

Datasheet
Code CSB-PA005077XA01DIL
Product Type Polyclonal Antibody
Uniprot No. Q8JH47
Delivery Make-to-order
Protocols ELISA Protocol
Immunogen Recombinant Danio rerio (Zebrafish) (Brachydanio rerio) CDK8 protein
Raised in Rabbit
Species Reactivity Danio rerio (Zebrafish) (Brachydanio rerio)
Tested Applications ELISA, WB (ensure identification of antigen)
Form Liquid
Conjugate Non-conjugated
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method Protein A/G
Isotype IgG
Clonality Polyclonal
Alias Cyclin-dependent kinase 8 (EC 2.7.11.22) (EC 2.7.11.23) (Cell division protein kinase 8) (Mediator complex subunit cdk8) (Mediator of RNA polymerase II transcription subunit cdk8) cdk8
Immunogen Species Danio rerio (Zebrafish) (Brachydanio rerio)
Gene Names cdk8
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex (By similarity).
Subcellular Location Nucleus
Protein Families Protein kinase superfamily, CMGC Ser/Thr protein kinase family, CDC2/CDKX subfamily
Database Links

STRING: 7955.ENSDARP00000022588

UniGene: Dr.82150

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