cds1 Antibody

Code CSB-PA600600XA01SXV
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Product Details

Full Product Name Rabbit anti-Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) cds1 Polyclonal antibody
Uniprot No. Q09170
Target Names cds1
Alternative Names cds1 antibody; SPCC18B5.11cSerine/threonine-protein kinase cds1 antibody; EC 2.7.11.1 antibody; Checkpoint kinase cds1 antibody
Raised in Rabbit
Species Reactivity Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Immunogen Recombinant Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) cds1 protein
Immunogen Species Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Conjugate Non-conjugated
Clonality Polyclonal
Isotype IgG
Purification Method Protein A/G
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form Liquid
Tested Applications ELISA, WB (ensure identification of antigen)
Protocols ELISA Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables ① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee ① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time Made-to-order (14-16 weeks)

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Target Background

Function
(From Uniprot)
Has a role in the DNA replication-monitoring S/G2 checkpoint system. It is responsible for blocking mitosis in the S phase. It monitors DNA synthesis by interacting with DNA polymerase alpha and sends a signal to block the onset of mitosis while DNA synthesis is in progress. Phosphorylates rad60 and dna2.
Gene References into Functions
  1. The prolongation in mutants deficient in meiotic DNA replication, was caused by the Cds1-dependent replication checkpoint, which represses expression of the mei4(+) gene encoding a meiosis-specific transcription factor. PMID: 25492408
  2. Cki3 acts downstream of the checkpoint kinase Cds1/Chk2 and calcineurin, and the latter physically interacts with Cki3. PMID: 25691662
  3. Rad60 phosphorylation is required to regulate homologous recombination at stalled replication forks, probably by regulating Smc5/6. PMID: 19755492
  4. the existence in fission yeast of a short variant (Sv) of Cds1 that is produced through an alternative splicing mechanism leading to a frame shift and premature termination PMID: 15467464
  5. Replication checkpoint kinase Cds1 regulates Mus81 (a subunit of the Mus81-Eme1 structure-specific endonuclease) by phosphorylation, to preserve genome integrity during replication stress. PMID: 15805465
  6. Rad3-Cds1 meiotic checkpoint pathway may target transcription of these factors. PMID: 16286472
  7. DNA-damage checkpoint pathways mediated by Cds1 and Rad3. PMID: 18154680
  8. These data show that by releasing Flp1p into the nucleus Cds1p checkpoint kinase modulates its own full activation during replication stress. PMID: 18385517
  9. Clr6-HDAC (histone deacetylase) regulates the checkpoint kinase Cds1 when DNA replication encounters a stressful condition. PMID: 18440981
  10. nap1 cds1 mutant cells lose viability and cells show positive histone phosphorylation, suggesting that the viability of nap1-deleted cells is due to the Cds1 kinase. PMID: 18474252
  11. Mrc1 that prevent activation of Cds1 have no effect on its ability to support rid mutant viability, suggesting that Mrc1 has a checkpoint-independent role in maintaining the viability of mutants defective in DNA replication initiation PMID: 18667534
  12. Phosphorylation of Nrm1 by the Cds1 (Chk2) checkpoint protein kinase, which is activated in response to DNA replication stress, promotes its dissociation from the MBF transcription factor. PMID: 18682565
  13. Cds1-dependent stabilization of Rep2 is achieved through the inhibition/phosphorylation of APC/C-Ste9 at the onset of S-phase arrest. PMID: 19596787

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Protein Families Protein kinase superfamily, CAMK Ser/Thr protein kinase family, CHEK2 subfamily
Database Links

KEGG: spo:SPCC18B5.11c

STRING: 4896.SPCC18B5.11c.1

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