ced-9 Antibody

1. HBx interacts directly with the B-cell lymphoma 2 (Bcl-2) homolog CED-9 (cell death abnormal) through a Bcl-2 homology 3 (BH3)-like motif to trigger both cytosolic Ca(2+) increase and cell death. PMID: 23091037
2. propose that EGL-1 converts CED-9 into a mitochondrial receptor for DRP-1, thereby shifting its activity from profusion to profission. PMID: 21949250
3. CED-9 retains the amphitropic ability of mammalian Bcl-2 proteins to associate with cellular membranes. PMID: 21031486
4. CED-9 forms a 2 : 2 heterotetrameric complex with CED-4 until specifically displaced by Caenorhabditis elegans, but not mammalian, BH3-only proteins. PMID: 16167070
5. Here, we show that CED-9 interacts with Mitofusin-2/fuzzy onions and can promote mitochondrial clustering and dramatic reorganization of mitochondrial networks. PMID: 16543146
6. these data are consistent with a multimodal character of CED-9 action, with an ability to regulate apoptosis through interactions in the cytosol coexisting with additional evolutionarily conserved role(s) at the membrane PMID: 17703231
7. while bcl-2 proteins are not required for ceramide to form protein-permeable channels in mitochondrial outer membranes, both recombinant human Bcl-x(L) and CED-9 disassemble ceramide channels in the mitochondrial outer membranes from rat liver and yeast PMID: 18171672
8. CED-9 is capable of regulating the mitochondrial fission-fusion cycle but is not essential for either fission or fusion. PMID: 18827010
9. Ced-9 promotes Al tolerance in plants via inhibition of Al-induced programmed cell death. PMID: 19341713

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KEGG: cel:CELE_T07C4.8

STRING: 6239.T07C4.8

UniGene: Cel.6305