CELA1 Antibody

1. insights into the PPE and HNE inhibition PMID: 26372354
2. Here, we studied the priming of SARS-CoV S by elastase and show an important role for residue Thr(795) in the S2 domain. PMID: 20507992
3. comparison of x-ray structures of alpha1PI complexes with trypsin, PPE, and human neutrophil elastase PMID: 16321984
4. Results describe mapping of the binding surface of porcine pancreatic elastase. PMID: 16488429
5. crystal structure of PPE complexed with a novel trimacrocyclic peptide inhibitor, FR901451, was solved at 1.9 A resolution PMID: 16511165
6. The crystal structure of the acyl complex of porcine pancreatic elastase with its peptidyl ester substrate N-acetyl-ala-ala-ala-methyl ester (Ac(Ala)3OMe) has been determined at 2.5 A resolution PMID: 17083959
7. Porcine pancreatic elastase (PPE) was crystallized in complex with a novel inhibitor at pH 5 and X-ray diffraction data were collected at a synchrotron source to 1.66 A. PMID: 17266656
8. the oxygen of the oxopropyl group of the inhibitor is present as an oxygen anion rather than a hydroxyl group, supporting the role of the "oxyanion hole" in stabilizing the tetrahedral intermediate in ELS1 catalysis PMID: 19603802

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KEGG: ssc:396766

STRING: 9823.ENSSSCP00000026330

UniGene: Ssc.5575