CENPA Antibody

Datasheet
Code CSB-PA773864XA01DIL
Product Type Polyclonal Antibody
Uniprot No. Q803H4
Delivery Make-to-order
Immunogen Recombinant Danio rerio (Zebrafish) (Brachydanio rerio) CENPA protein
Raised in Rabbit
Species Reactivity Danio rerio (Zebrafish) (Brachydanio rerio)
Tested Applications ELISA, WB (ensure identification of antigen)
Form Liquid
Conjugate Non-conjugate
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method Protein A/G
Isotype IgG
Clonality Polyclonal
Alias Histone H3-like centromeric protein A (Centromere protein A) (CENP-A) cenpa
Immunogen Species Danio rerio (Zebrafish) (Brachydanio rerio)
Protocols ELISA Protocol
Gene Names cenpa
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Histone H3-like nucleosomal protein that is specifically found in centromeric nucleosomes. Replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore. The presence of CENPA subtly modifies the nucleosome structure and the way DNA is wrapped around the nucleosome and gives rise to protruding DNA ends that are less well-ordered and rigid compared to nucleosomes containing histone H3. May serve as an epigenetic mark that propagates centromere identity through replication and cell division. Required for recruitment and assembly of kinetochore proteins, and as a consequence required for progress through mitosis, chromosome segregation and cytokinesis.
Subcellular Location Nucleus, Chromosome, centromere, kinetochore, Chromosome, centromere
Protein Families Histone H3 family
Database Links

KEGG: dre:100302659

STRING: 7955.ENSDARP00000126317

UniGene: Dr.162045

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