CERK1 Antibody

1. Arabidopsis pattern-recognition receptor chitin elicitor receptor kinase 1 (CERK1) is autophosphorylated in unstimulated cells at tyrosine(428), a modification that is required for CERK1 activation upon binding to the fungal cell wall component chitin. PMID: 29396039
2. These data support that plants, like animals, have selected as microbe-associated molecular patterns (MAMPs) the linear 1,3-beta-d-glucans present in the walls of fungi and oomycetes. The data also suggest that CERK1 functions as an immune co-receptor for linear 1,3-beta-d-glucans in a similar way to its proposed function in the recognition of fungal chito-oligosaccharides and bacterial peptidoglycan MAMPs. PMID: 29083116
3. Nucleoporin NUP88/MOS7 is required for manifestation of phenotypes associated with the Arabidopsis CHITIN ELICITOR RECEPTOR KINASE1 mutant cerk1-4 PMID: 28387602
4. Study indicated that CERK1 physically interacts with ANNEXIN 1 (ANN1), which was reported to form a calcium-permeable channel that contributes to the NaCl-induced [Ca(2+) ]cyt signal. In turn, ann1 mutants showed elevated chitin-induced rapid responses PMID: 27888535
5. PBL27 interacts with both CERK1 and the MAPK kinase kinase MAPKKK5 at the plasma membrane and knockout of MAPKKK5 compromise chitin-induced MAPK kinase activation and disease resistance to Alternaria brassicicola. PMID: 27679653
6. the phosphorylation of specific residues in the kinase domain of CERK1 contributes to the regulation of downstream signaling. PMID: 27565204
7. Cerk1 plays a chitin-independent role in a pathogen-induced cell death control. PMID: 25041086
8. pre-mRNA splicing plays important roles in the regulation of plant immunity mediated by the receptor-like kinases SNC4 and CERK1 PMID: 25267732
9. AtLYK5 is the primary receptor for chitin, forming a chitin inducible complex with AtCERK1 to induce plant immunity. PMID: 25340959
10. LIK1 directly interacts with CERK1 and regulates MAMP-triggered innate immunity PMID: 25036661
11. PBL27, an Arabidopsis ortholog of OsRLCK185, is an immediate downstream component of CERK1 and contributes to the regulation of chitin-induced immunity in Arabidopsis. PMID: 24750441
12. CERK1 is sufficient for chitin perception by itself in Arabidopsis PMID: 22891159
13. CREK1/LysM RLK1 receptor is a key component in mediating stress responses. PMID: 22461667
14. crystal structure an CERK1-ECD complexed with a chitin pentamer reveals that their interaction is primarily mediated by a LysM and 3 chitin residues; by acting as a bivalent ligand, a chitin octamer induces CERK1-ECD dimerization; data support the notion that chitin-induced CERK1 dimerization is critical for its activation PMID: 22654057
15. Data show that deletion of CERK1 (At3g21630) phenocopies defects observed in lym1 (At1g21880) and lym3 (At1g77630) mutants, such as peptidoglycan insensitivity and enhanced susceptibility to bacterial infection. PMID: 22106285
16. CERK1 is a major chitin, chitosan, and chito-oligomer binding component and that chitin signaling depends on CERK1 post-translational modification and kinase activity. PMID: 20610395
17. CERK1 plays a critical role in fungal microbe-associated molecular pattern perception in plants. PMID: 18042724
18. Results show that CERK1 is a determinant of bacterial immunity in Arabidopsis, but its contribution is overcome by bacteria expressing AvrPtoB. PMID: 19249211

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KEGG: ath:AT3G21630

STRING: 3702.AT3G21630.1

UniGene: At.5663