vvl Antibody

Code CSB-PA322271XA01DLU
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Product Details

Full Product Name
Rabbit anti-Drosophila melanogaster (Fruit fly) vvl Polyclonal antibody
Uniprot No.
Target Names
vvl
Alternative Names
vvl antibody; Cf1a antibody; CG10037POU domain protein CF1A antibody; Chorion factor 1A antibody; CF1-A antibody; Protein drifter antibody; Ventral veins lacking protein antibody
Raised in
Rabbit
Species Reactivity
Drosophila melanogaster (Fruit fly)
Immunogen
Recombinant Drosophila melanogaster (Fruit fly) vvl protein
Immunogen Species
Drosophila melanogaster (Fruit fly)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Protein A/G
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Binds to a DNA sequence element required for the expression of the dopa decarboxylase gene (Ddc) in specific dopaminergic neurons. Could also play an early role in specific ectodermal cells, and a subsequent role in the embryonic nervous system.
Gene References into Functions
  1. Vvl is highly expressed in the prothoracic gland during embryogenesis and is enriched in the gland during larval development, suggesting that Vvl might function as a master transcriptional regulator in this tissue. PMID: 24945799
  2. Dfr/Vvl is highly expressed in a range of immunocompetent tissues, including the male ejaculatory duct, where its presence overlaps with and drives the expression of cecropin PMID: 20457811
  3. From lineage to wiring specificity. POU domain transcription factors control precise connections of Drosophila olfactory projection neurons. PMID: 12553905
  4. multiple roles for u-turn/ventral veinless in the development of the peripheral nervous system PMID: 12702660
  5. vvl acts downstream of the Hox gene lab and regulates specific aspects of neuronal differentiation within the tritocerebral neuromere during embryonic brain development PMID: 16326080

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Subcellular Location
Nucleus.
Protein Families
POU transcription factor family, Class-3 subfamily
Tissue Specificity
Coexpressed with acj6 in overlapping subsets of neurons in the embryonic epidermis and central nervous system. First detected in the precursor of the tracheal pits and the stomodeal invagination and later in the peripheral nervous system.
Database Links

KEGG: dme:Dmel_CG10037

STRING: 7227.FBpp0303092

UniGene: Dm.2556

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