CHAC1 Antibody

Code CSB-PA735944XA01DIL
Product Type Polyclonal Antibody
Uniprot No. Q5SPB6
Delivery Make-to-order
Protocols ELISA Protocol
Immunogen Recombinant Danio rerio (Zebrafish) (Brachydanio rerio) CHAC1 protein
Raised in Rabbit
Species Reactivity Danio rerio (Zebrafish) (Brachydanio rerio)
Tested Applications ELISA, WB (ensure identification of antigen)
Form Liquid
Conjugate Non-conjugated
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method Protein A/G
Isotype IgG
Clonality Polyclonal
Alias Glutathione-specific gamma-glutamylcyclotransferase 1 (Gamma-GCG 1) (EC 4.3.2.-) (Cation transport regulator-like protein 1) chac1
Immunogen Species Danio rerio (Zebrafish) (Brachydanio rerio)
Gene Names chac1
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides. Glutathione depletion is an important factor for apoptosis initiation and execution. Acts as a pro-apoptotic component of the unfolded protein response pathway by mediating the pro-apoptotic effects of the ATF4-ATF3-DDIT3/CHOP cascade. Negative regulator of Notch signaling pathway involved in embryonic neurogenesis
Subcellular Location Cytoplasm, cytosol, Golgi apparatus, trans-Golgi network
Protein Families Gamma-glutamylcyclotransferase family, ChaC subfamily
Database Links

KEGG: dre:563855

STRING: 7955.ENSDARP00000094107

UniGene: Dr.76600

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