CHD8 Antibody

Code CSB-PA005333XA01DIL
Product Type Polyclonal Antibody
Uniprot No. B0R0I6
Delivery Make-to-order
Protocols ELISA Protocol
Immunogen Recombinant Danio rerio (Zebrafish) (Brachydanio rerio) CHD8 protein
Raised in Rabbit
Species Reactivity Danio rerio (Zebrafish) (Brachydanio rerio)
Tested Applications ELISA, WB (ensure identification of antigen)
Form Liquid
Conjugate Non-conjugated
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method Protein A/G
Isotype IgG
Clonality Polyclonal
Alias Chromodomain-helicase-DNA-binding protein 8 (CHD-8) (EC (ATP-dependent helicase CHD8) chd8 si:ch211-10e2.6 wu:fi45h08
Immunogen Species Danio rerio (Zebrafish) (Brachydanio rerio)
Gene Names chd8
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/tp53-mediated apoptosis by recruiting histone H1 and preventing p53/tp53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (ctnnb1) activity. Negatively regulates ctnnb1-targeted gene expression by being recruited specifically to the promoter regions of several ctnnb1 responsive genes. May also act as a transcription activator by participating in efficient U6 RNA polymerase III transcription.
Subcellular Location Nucleus
Protein Families SNF2/RAD54 helicase family, CHD8 subfamily
Database Links

STRING: 7955.ENSDARP00000122217

UniGene: Dr.81397

Pathway Wnt signaling pathway

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