grp Antibody

1. Grp was assumed to play a direct role in the immune response in D. melanogaster. PMID: 27414781
2. The Grp gene is expressed at the adult stage of D. melanogaster in gender-specific and tissue-specific manner. PMID: 24503082
3. The Grp gene has been demonstrated to be a functional gene in the D. melanogaster genome, bit its function is yet to be determined. PMID: 22117415
4. the Grp gene is not a pseudogene, but it is a functional gene of the D. melanogaster genome whose role remains to be elucidated. PMID: 21954611
5. A genetic screen identified grapes, the gene that encodes the Drosophila orthologue of checkpoint kinase 1 (CHK1). Knockdown of grapes by RNAi rescued eye development despite ongoing PERK activation. PMID: 20682638
6. Grp/DChk1, and not Dmnk/DChk2, is the main effector kinase involved in G(2)/M checkpoint control in Drosophila cells PMID: 15860729
7. Embryos mutant for grp, which encodes Chk1, are DNA-replication-checkpoint defective and fail to cellularize, gastrulate or to initiate high-level zygotic transcription at the midblastula transition. PMID: 17409117
8. Grp(Chk1) prevents nuclear CDK1 activation by delaying CycB nuclear accumulation through Wee1-dependent and independent mechanisms. PMID: 18824564
9. The Grp gene product has a highly conserved structure in different species of the Drosophilidae family and is under stabilizing selection, which suggests its important genomic function in Drosophila. PMID: 19239094

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KEGG: dme:Dmel_CG17161

STRING: 7227.FBpp0080441

UniGene: Dm.7018