chk-2 Antibody

Code CSB-PA886970XA01CXY
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Product Details

Full Product Name
Rabbit anti-Caenorhabditis elegans chk-2 Polyclonal antibody
Uniprot No.
Target Names
chk-2
Alternative Names
chk-2 antibody; cds-1 antibody; Y60A3A.12Serine/threonine-protein kinase chk-2 antibody; EC 2.7.11.1 antibody; Ce-cds-1 antibody; Ce-chk-2 antibody
Raised in
Rabbit
Species Reactivity
Caenorhabditis elegans
Immunogen
Recombinant Caenorhabditis elegans chk-2 protein
Immunogen Species
Caenorhabditis elegans
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest, activation of DNA repair and apoptosis in response to the presence of DNA double-strand breaks. May also negatively regulate cell cycle progression during unperturbed cell cycles. Phosphorylates and inhibits cdc25 phosphatase, preventing entry into mitosis. Required for nuclear reorganization and homologous chromosome pairing during meiotic prophase.
Subcellular Location
Nucleus.
Protein Families
Protein kinase superfamily, CAMK Ser/Thr protein kinase family, CHK2 subfamily
Tissue Specificity
Highly expressed in germline tissue.
Database Links
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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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