cic Antibody

1. Data indicate that the HMG-box of Capicua (CIC) does not bind DNA alone but instead requires a distant motif (referred to as C1) present at the C-terminus of all CIC proteins. PMID: 28278156
2. Thus, Cic proteins employ distinct repressor mechanisms that are associated with discrete structural changes in the evolutionary history of this protein family. PMID: 25569482
3. Capicua directly interacts with several corepressor-binding sites in the zerknullt ventral repression element. PMID: 25059278
4. We propose that ERK-dependent relief of gene repression by Cic is a two-step process, in which fast reduction of repressor activity is followed by slower changes in nuclear localization and overall protein levels. PMID: 23733957
5. [REVIEW] Capicua (CIC) is a key sensor of receptor tyrosine kinase (RTK) signaling in both Drosophila and mammals. PMID: 22526417
6. Feedback regulation by bantam on Capicua provides a means to link signal propagation by the EGFR pathway to activity of the Hippo pathway and may play an important role in integration of these two pathways in growth control. PMID: 22445297
7. The terminal and posterior systems function coordinately to alleviate transcriptional silencing by Capicua PMID: 15510215
8. ATXN1 directly binds Capicua and modulates Capicua repressor activity in Drosophila and mammalian cells, and its loss decreases the steady-state level of Capicua. PMID: 17190598
9. A MAPK docking site in Capicua is critical for its downregulation by Torso and EGFR RTK signaling. PMID: 17255944
10. findings show Capicua restricts cell growth in imaginal discs, and its levels are, in turn, downregulated by Ras signaling; thus Cic is a key downstream component in the pathway by which Ras regulates growth in imaginal discs PMID: 17398096

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KEGG: dme:Dmel_CG43122

STRING: 7227.FBpp0293566

UniGene: Dm.5727