cid Antibody

Datasheet

Code	CSB-PA893714XA01DLU
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Target Background

Product Details

Full Product Name

Rabbit anti-Drosophila melanogaster (Fruit fly) cid Polyclonal antibody

Uniprot No.

Q9V6Q2

Target Names

cid

Alternative Names

CENP A antibody; CENP-A homolog antibody; CENPA / CID antibody; CENPA antibody; Centromere identifier antibody; Centromere identifier protein antibody; Centromere protein A antibody; cid antibody; CID/CENP A antibody; CID_DROME antibody; Histone H3 like centromeric protein cid antibody; Histone H3-like centromeric protein cid antibody

Raised in

Rabbit

Species Reactivity

Drosophila melanogaster (Fruit fly)

Immunogen

Recombinant Drosophila melanogaster (Fruit fly) cid protein

Immunogen Species

Drosophila melanogaster (Fruit fly)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

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Target Background

Function

Histone H3-like variant which exclusively replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore. Required for recruitment and assembly of kinetochore proteins, mitotic progression and chromosome segregation. May serve as an epigenetic mark that propagates centromere identity through replication and cell division.

Gene References into Functions

ATP synthase F1 subunits recruited to centromeres by CENP-A are required for male meiosis. PMID: 30006572
centromere assembly factors CAL1 and CENP-C are required for meiotic chromosome segregation, CENP-A assembly and maintenance on sperm, as well as fertility PMID: 27095496
identify two co-evolving regions, CENP-A L1 and the CAL1 N terminus, as critical for lineage-specific CENP-A incorporation PMID: 27093083
A novel role has been described for the histone acetyltransferase Hat1 in the CENP-A/CID assembly pathway in Drosophila melanogaster. PMID: 26586808
CENP-A assembly by its loading factor, CAL1, requires RNAPII-mediated transcription of the underlying DNA PMID: 26151904
The amount of Cid that is loaded during each cell cycle appears to be determined primarily by the preexisting centromeric Cid, with little flexibility for compensation of accidental losses. PMID: 23300376
CID nucleosomes are octameric in vivo and that CID dimerization is essential for correct centromere assembly. PMID: 22209075
The F box protein partner of paired (Ppa) mediates CenH3(CID) stability in Drosophila. Ppa depletion results in increased CenH3(CID) levels. Ppa physically interacts with CenH3(CID) through the CATD(CID) that mediates Ppa-dependent CenH3(CID) stability. PMID: 21871803
Drosophila CENP-C is essential for centromere identity. PMID: 20862486
Cid allows for contacts betwen DNA and histones and specific targeting PMID: 12370302
Results suggest that CID mislocalization promotes formation of ectopic centromeres and multicentric chromosomes, which causes chromosome missegregation, aneuploidy, and growth defects. PMID: 16516834
Proteasome-mediated degradation restricts localization of Drosophila CENP-A (CID) to centromeres by eliminating mislocalized CID as well as by regulating available CID levels. PMID: 17090596
Study shows by quantitative fluorescence measurements in living early embryos that functional fluorescent fusion proteins of the Drosophila CENP-A and CENP-C homologs are rapidly incorporated into centromeres during anaphase. PMID: 17222555

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Subcellular Location

Nucleus. Chromosome, centromere, kinetochore.

Protein Families

Histone H3 family

Database Links

KEGG: dme:Dmel_CG13329

STRING: 7227.FBpp0086787

UniGene: Dm.5691

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cid Antibody

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