CIN8 Antibody

1. Bidirectional Kinesin Cin8 Produce Additive Forces in Both Directions of Movement PMID: 29117528
2. Data suggest that approximately four Cin8 motor domains can bind each alpha/beta-tubulin dimer within microtubule lattice; Cin8 binds microtubules not only at the canonical site, but also one or more separate "non-canonical" sites. PMID: 28701465
3. The tail domain is one of the factors that regulate Cin8 directionality. PMID: 25991727
4. The deletion mutant cells exhibited reduced midzone-directed motility and efficiency to support spindle elongation, indicating the importance of directionality control for the anaphase function of Cin8. PMID: 22101328
5. Dephosphorylation of Cin8 promotes its binding to the spindle microtubules before the onset of anaphase. PMID: 21378308
6. Cin8 can switch between two states of directional motility. On individual microtubules, Cin8 motors move toward the minus end, they switch to plus-end movement when part of a team of mechanically coupled motors cross-linking antiparallel microtubules. PMID: 21350123
7. Data suggest that spindle disassembly is achieved by mechanistically distinct but functionally overlapping subprocesses, which are largely governed by the anaphase-promoting complex, Aurora B kinase, and kinesin-8. PMID: 21079246
8. Results suggest that binding of microtubules is not sufficient for the functionality of Cin8p and that microtubule cross-linking by the tetrameric complex is essential for Cin8p mitotic functions. PMID: 16829678
9. Spindle elongation in anaphase in Saccharomyces cerevisiae cells mutated for the kinesin-5 motor protein Cin8 PMID: 18628309
10. Data observed that deletion of Cin8, a microtubule-crosslinking kinesin-5 motor protein, reduced the recovery rate in anaphase spindles, indicating that Cin8 contributes to the destabilization of iMT plus-ends. PMID: 19270715

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KEGG: sce:YEL061C

STRING: 4932.YEL061C