clk-2 Antibody

Code CSB-PA836128XA01CXY
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Product Details

Full Product Name
Rabbit anti-Caenorhabditis elegans clk-2 Polyclonal antibody
Uniprot No.
Target Names
clk-2
Alternative Names
clk-2 antibody; rad-5 antibody; C07H6.6Telomere length regulation protein clk-2 antibody; Clock abnormal protein 2 antibody
Raised in
Rabbit
Species Reactivity
Caenorhabditis elegans
Immunogen
Recombinant Caenorhabditis elegans clk-2 protein
Immunogen Species
Caenorhabditis elegans
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
DNA damage checkpoint protein required for DNA damage-induced cell cycle arrest and apoptosis, thereby playing a role in genome stability. Regulator of telomere length.
Gene References into Functions
  1. DNA damage checkpoint protein clk-2 suppresses the frequency of mutation by ensuring that spontaneous DNA damage is accurately repaired in C. elegans germ cells. PMID: 16951081
  2. Persistent repair intermediates and/or single-stranded DNA formed during repair of misincorporated uracil are tolerated in the absence of the CLK-2 checkpoint in C. elegans. PMID: 16964178
  3. Clk-2 mutants accumulate genomic instability and show a delay of embryonic cell cycle timing. PMID: 19360121
Subcellular Location
Nucleus. Chromosome, telomere.
Protein Families
TEL2 family
Database Links

KEGG: cel:CELE_C07H6.6

STRING: 6239.C07H6.6

UniGene: Cel.32199

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