CLV3 Antibody

1. The hypothesis explains how the WUSCHEL gene product, synthesized basally in the meristem, induces CLAVATA3-expressing stem cells in the meristem apex but, paradoxically, not in the basal domain where WUSCHEL itself is expressed. The answer involves the activity of the small family of HAIRY MERISTEM genes, which prevent the activation of CLAVATA3 and which are expressed basally in the shoot meristem. PMID: 30072538
2. In shoot apical meristem, FHY3 directly represses CLV3, which consequently regulates WUS to maintain the stem cell pool. PMID: 27469166
3. structures provide insights about the ligand perception and specific interactions between the CLE peptides and their cognate receptors PMID: 28384649
4. CLV3 ligand/CLV1 receptor system initiates a signaling cascade that elevates cytosolic Ca(2+). This cytosolic secondary messenger is involved in the signal transduction cascade linking CLV3/CLV1 to control of gene expression and stem cell fate in the shoot apical meristem (SAM). PMID: 26756833
5. Gene NANA regulates cell proliferation in Arabidopsis thaliana shoot apical meristem without interaction with CLV3. PMID: 25752149
6. These results suggest that 5-amino acid residues flanking the N-terminus of CLV3 peptide are required for proper cleavages and optimal function in stem cell regulation. PMID: 24369789
7. The spatial expression of the two components (WUS and CLV3) of a regulatory network maintaining shoot meristem (SM)stem cells resembles that seen in a vegetative shoot apical meristem, suggesting the rapid initiation and establishment of the new SMs. PMID: 23181633
8. The arabinose chain length of CLV3 is important for its biological activity. PMID: 23256149
9. Exogenous CLV3 does not trigger FLS2-dependent immune responses. PMID: 22923673
10. These studies established a complete contribution map of individual residues in the peptide-coding region of CLV3 for its function in shoot apical meristem. PMID: 22259020
11. Data show that the CLAVATA 3 (CLV3) gene, a stem cell marker in shoot apical meristem (SAM), was expressed in expanded regions surrounding the SAM of nsn1 plants. PMID: 22058024
12. Downregulation of plasma membrane-localized CLV1 by its CLV3 ligand can account for the buffering of CLV3 signaling in the maintenance of stem cell pools in plants. PMID: 21333538
13. CLAVATA3 peptide (CLV3p), expressed and secreted from stem cells and functioning as a key regulator of stem-cell homeostasis in the shoot apical meristem, can trigger immune signalling and pathogen resistance via the flagellin receptor kinase FLS2 PMID: 21499263
14. Data show that CLV3 protein CLE processing activity the in vitro cleavage occurs at Arg70, exactly matching in vivo maturation. PMID: 21052783
15. In vitro peptide assay also showed that removal of the cysteine pairs did not affect the perception of CLV3 peptides in roots PMID: 20738721
16. These observations suggest that RPK2 is an essential component of an independent third pathway for CLV3 signalling PMID: 20978082
17. Data show that CRN, rather than CLV1 and CLV2, was able to form homodimers without CLV3 stimulation. PMID: 19843317
18. Data suggest that CLV3, CLE19 and CLE40 peptides represent the major active domain of the CLE proteins, which interact with an unknown cell identity-maintaining CLAVATA2 receptor complex in roots, leading to consumption of the root meristem. PMID: 16055633
19. study provides evidence that CLV3 signaling in meristems mediates both cell fate specification and growth control through inhibition of cell division rate, as well as that the processes can be temporally uncoupled PMID: 16210497
20. Increased CLV3 signaling restricts meristem growth and promotes allocation of peripheral meristem cells into organ primordia. PMID: 16603652
21. The CLV3/ESR (CLE) motif is the functional region of the CLV3 protein and it acts independently of the adjacent sequences. PMID: 16751438
22. structure of a modified peptide (MCLV3), derived from a conserved motif in the CLV3 sequence; synthetic MCLV3 induced shoot & root meristem consumption as cells differentiated into other organs; results suggest the functional peptide of CLV3 is MCLV3 PMID: 16902141
23. biochemical evidence shows that the CLV3 peptide directly binds the CLV1 ectodomain with a dissociation constant of 17.5 nM; results provide direct evidence that CLV3 and CLV1 function as a ligand-receptor pair involved in stem cell maintenance PMID: 18202283
24. the novel receptor kinase CORYNE (CRN) and CLV2 act together, and in parallel with CLV1, to perceive the CLV3 signal PMID: 18381924
25. The terminal residues of MCLV3 play critical roles in exerting its activity and are important for specific binding to the receptor, CLV1. PMID: 18848920
26. Early development of the flower primordium has been studied in Arabidopsis thaliana clavata3-2 (clv3-2) plants with the aid of sequential in vivo replicas and longitudinal microtome sections. PMID: 19088334

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KEGG: ath:AT2G27250

STRING: 3702.AT2G27250.3

UniGene: At.38793