Product Details

Full Product Name

Rabbit anti-Drosophila melanogaster (Fruit fly) cnc Polyclonal antibody

Uniprot No.

P20482

Target Names

cnc

Alternative Names

cnc antibody; CG43286Segmentation protein cap'n'collar antibody

Raised in

Rabbit

Species Reactivity

Drosophila melanogaster (Fruit fly)

Immunogen

Recombinant Drosophila melanogaster (Fruit fly) cnc protein

Immunogen Species

Drosophila melanogaster (Fruit fly)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Target Background

Function

Plays a role in posterior cephalic patterning. Probable subunit of a heterodimeric regulatory protein involved in the control of head morphogenesis. Isoform B may have a repressive effect on Dfd response elements, thereby modifying the activity and specificity of the Hox system and moving the body anterior/posterior axis.

Gene References into Functions

continual knockdown of Keep1 (the cytosolic inhibitor of Cnc-C) in adults resulted in older flies with greater stress resistance than their age-matched controls, but who still exhibited an age-associated loss of adaptive homeostasis PMID: 28373600
Cnc is required for tissue regeneration. Cnc regulates reactive oxygen species levels in the regenerating wing imaginal disc, and affects JNK signaling. PMID: 28512185
Selective expression of the Nrf2 homologous gene cncC in the dopaminergic neurons effectively protected against the neurodegenerative phenotype of the A53T alpha-synuclein flies, compared to the flies that expressed cncC in all neurons PMID: 26008822
CncCDeltaN induced a number of genes related to innate immunity that might have an effect on the regulation of cellular lipid storage PMID: 26049108
Upregulation of the Nrf2 pathway by overexpressing Nrf2 or its DNA-binding dimerization partner, Maf-S, restores the locomotor activity of alpha-synuclein-expressing flies. PMID: 21719443
Basic leucine zipper protein Cnc-C is a substrate and transcriptional regulator of the 26S proteasome. PMID: 21149573

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Subcellular Location

Nucleus.

Protein Families

BZIP family, CNC subfamily

Tissue Specificity

Embryonic expression of isoform B is localized to the mandibular segment and the hypopharyngeal and labral primordia first detectable in late blastoderm stages. Embryonic expression of isoforms B and C is ubiquitous.

Database Links

KEGG: dme:Dmel_CG43286

STRING: 7227.FBpp0303398

UniGene: Dm.3705

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cnc Antibody

Product Details

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Target Background