Product Details

Full Product Name

Rabbit anti-Caenorhabditis elegans tax-4 Polyclonal antibody

Uniprot No.

Q03611

Target Names

tax-4

Alternative Names

tax-4 antibody; ZC84.2Cyclic nucleotide-gated cation channel antibody; Abnormal chemotaxis protein 4 antibody

Raised in

Rabbit

Species Reactivity

Caenorhabditis elegans

Immunogen

Recombinant Caenorhabditis elegans tax-4 protein

Immunogen Species

Caenorhabditis elegans

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

Target Background

Function

Required for normal thermosensation and chemosensation sensory behavior. Required, downstream of receptor-type guanylate cyclase gcy-9, for CO2-mediated responses in BAG neurons. Required, downstream of receptor-type guanylate cyclase gcy-14, for alkaline pH-mediated responses in ASE-left (ASEL) neurons. Involved in the development of ASJ sensory neuron axon during late larval stages and in the maintenance of normal axon morphology in the adult. Regulates dauer formation. Required for the calcium flux to the cytoplasm in the ASJ sensory neurons upon the onset and removal of a nitric oxide (NO) stimulus, thereby promoting the ASJ-mediated behavioral avoidance response to NO-producing organisms like P.aeruginosa. In ASI and ASJ sensory neurons, controls behavioral response to P.aeruginosa by up-regulating the transcription of daf-7, a member of the TGF-beta family. In AWB and AWC sensory neurons, mediates the recognition of food odors which subsequently allows for the detection of preferred food sources. In AWC neurons, acts to promote expression of srsx-3, a member of the GPCR family.

Gene References into Functions

tax-4 cryo-electron microscopy structure provides a new framework for understanding mechanisms of ion permeation, gating and channelopathy of cyclic-nucleotide-gated channels and cyclic nucleotide modulation of related channels PMID: 28099415
Mutants in tax-4 showed abnormal thermal responses, suggesting that these genes are involved in warm avoidance. PMID: 12819265
Wild-type worms are induced to display an L1 (first larval stage) surface epitope at later larval stages when grown on an extract of spent culture medium; this was abolished in chemotaxis-defective tax-4 mutants. PMID: 16879619

Subcellular Location

Membrane; Multi-pass membrane protein.

Protein Families

Cyclic nucleotide-gated cation channel (TC 1.A.1.5) family

Tissue Specificity

Expressed at the sensory endings of thermosensory, gustatory, and olfactory neurons.

Database Links

KEGG: cel:CELE_ZC84.2

STRING: 6239.ZC84.2

UniGene: Cel.19693

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tax-4 Antibody

Product Details

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Target Background