CNGC2 Antibody

Code CSB-PA527733XA01DOA
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Product Details

Full Product Name
Rabbit anti-Arabidopsis thaliana (Mouse-ear cress) CNGC2 Polyclonal antibody
Uniprot No.
Target Names
Alternative Names
CNGC2; DND1; At5g15410; T20K14_20; Cyclic nucleotide-gated ion channel 2; AtCNGC2; Cyclic nucleotide- and calmodulin-regulated ion channel 2; Protein DEFENSE NO DEATH 1
Raised in
Species Reactivity
Arabidopsis thaliana
Recombinant Arabidopsis thaliana CNGC2 protein
Immunogen Species
Arabidopsis thaliana (Mouse-ear cress)
Purification Method
Antigen Affinity Purified
It differs from different batches. Please contact us to confirm it.
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Tested Applications
ELISA, WB (ensure identification of antigen)
Troubleshooting and FAQs
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Acts as cyclic nucleotide-gated ion channel. Permeable to potassium and calcium in a cyclic nucleotide-dependent fashion (cAMP or cGMP). Could also transport lithium, cesium and rubium and displays a strong selectivity against sodium. Seems to directly participate in pathogen-induced calcium influx. May function in homeostasis, re-establishing ionic balance after defense action and/or other stimuli. Could mediate the initiation of the developmentally regulated cell death programs.
Gene References into Functions
  1. These results suggest that the stage-dependent differences in heat stress response of Arabidopsis regulated by CNGC2 might rely on regulatory mechanisms of APX1-and MBF1c-dependent pathways and H2O2 homeostasis. PMID: 29275210
  2. CNGC2 is the key factor mediating Ca2+ influx into the leaf cells. PMID: 27999084
  3. results indicate that S gene function of DND1 is conserved in tomato and potato. We discuss the possibilities of using RNAi silencing or loss-of-function mutations of DND1 orthologs, as well as additional S gene orthologs from Arabidopsis, to breed for resistance to pathogens in crop plants. PMID: 26577903
  4. Arabidopsis thaliana cyclic nucleotide-gated channel 2 (AtCNGC2) is involved in jasmonic acid (JA)-induced apoplastic Ca(2+) influx in Arabidopsis epidermal cells. PMID: 26608645
  5. This indicates that AtCNGC2 and AtCNGC4 have a unique role controlling flowering timing and this function is independent from its role in pathogen defense. PMID: 25719935
  6. AtCNGC2 and AtCNGC4 are likely part of the same channel complex. PMID: 24027242
  7. Disruption of Arabidopsis CNGC2 impairs plant growth and heat sensing. PMID: 22904147
  8. Study expand the discussion of CNGC2 mediated Ca(2+) uptake and other related signaling components involved in the plant senescence signaling cascade. PMID: 21358265
  9. in a signaling cascade, the cGMP-activated channel CNGC2 is involved in AtPep- and PepR1-dependent inward Ca2+ conductance and resulting cytosolic Ca2+ elevation PMID: 21088220
  10. The CNGC2 loss-of-function mutant displays early senescence phenotypes and has a lower endogenous NO level in leaves compared to the wild-type . PMID: 20699402
  11. Arabidopsis thaliana CYCLIC NUCLEOTIDE GATED CHANNEL2 (CNGC2/DND1) conducts Ca(2+) into cells and provide a model linking this Ca(2+) current to downstream nitric oxide production. PMID: 17384171
  12. Transcriptional responses to growth in high environmental calcium concentrations were characterized and compared between wild-type and mutant Arabidopsis plants containing a knockout mutation in the gene encoding a cyclic nucleotide-gated channel (CNGC2). PMID: 18307990
  13. The findings indicate that the broad-spectrum resistance of dnd1 mutants occurs due to activation or sensitization of multiple defense pathways, yet none of the investigated pathways are required for the reduced-HR phenotype. PMID: 18785824
  14. sporophytic, but not gametophytic, defects are the main cause of the observed reduction in seed yield in cngc2 plants, and suggest that correct cyclic nucleotide and calcium signaling are important for cell elongation and pollen tube guidance. PMID: 19368669

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Subcellular Location
Cell membrane; Multi-pass membrane protein.
Protein Families
Cyclic nucleotide-gated cation channel (TC 1.A.1.5) family
Tissue Specificity
Expressed in the whole plant but only weakly in roots. Strongly expressed in the expanded cotyledons of 14-day-old seedlings and detected later in leaves after the transition to flowering. Also detected in flowers during organ senescence and in the dehisc
Database Links

KEGG: ath:AT5G15410

STRING: 3702.AT5G15410.1

UniGene: At.20813

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