Col4a1 Antibody

1. Results provide evidence that collagen IV produced in adipocytes is transported to the ovary to maintain proper germline stem cell (GSC) number in adult Drosophila females. Adipocyte-derived collagen IV acts through beta-integrin signaling to maintain normal levels of E-cadherin at the niche, thereby ensuring proper adhesion to GSCs. PMID: 29884747
2. The results demonstrated that col4a1 mutations affect the epithelia and, consequently, secretory function of the Malpighian tubules PMID: 29651426
3. Results of phenotypic features of Drosophila col4a1 mutants confirmed an essential role for type IV collagen in maintaining epithelial integrity, gut morphology and intestinal function and suggest that aberrant structure and function of the COL4A1 protein may also be a significant factor in modulating immunity. PMID: 26363084
4. Data show that laminin beta and collagen IV alpha1 were involved in cardiac and muscular abnormalities. PMID: 24935095
5. Drosophila basement membrane collagen col4a1 mutations cause severe myopathy. PMID: 22037604
6. Data suggest that collagen IV acts to enhance ligand presentation to tubule cell receptors and is required to ensure ligand-mediated activation of the BMP pathway. PMID: 20708591

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KEGG: dme:Dmel_CG4145

STRING: 7227.FBpp0078641

UniGene: Dm.5178