Cyp26b1 Antibody

1. This study concluded that retinoic acid and STRA8 are conserved factors that control the initiation of meiosis amongst mammals but the role of CYP26B1 as a meiosis-inhibiting factor may be specific to rodents. PMID: 29044428
2. elimination of CYP26B1 activity within both germ and Sertoli cells resulted in severe male subfertility, with a loss of advanced germ cells from the seminiferous epithelium. PMID: 26040672
3. The results of this study concluded that stimulus-dependent neuronal activity can control the expression of the RA catabolic enzyme Cyp26B1 and downstream genes such as BACE1. PMID: 24797530
4. The study showed that a stimulus-dependent gradient of a retinoic acid-inactivating enzyme Cyp26B1 modifies the composition, localization PMID: 26446231
5. Cyp26b1 in the growth plate regulates the proliferation rates of chondrocytes and is responsible for the normal function of the growth plate and growing bones PMID: 25305491
6. results show that T cell-specific expression of Cyp26b1 is required for the development of T cell-mediated colitis and may be applicable to the development of therapeutics that target Cyp26b1 for the treatment of inflammatory bowel disease PMID: 23991089
7. CYP26B1 suppresses two distinct genetic programs induced by retinoic acid: a Stra8-dependent meiotic pathway, and a Stra8-independent mitotic pathway. PMID: 24576537
8. CYP26B1 has a role in regulating retinoid levels and is important for lymphatic vascular development in the mouse embryo PMID: 24361262
9. Data demonstrated that CYP26B1 is essential during palatogenesis. The regulation of endogenous retinoic acid level through CYP26B1 is required for elevation of palatal shelves. PMID: 22972661
10. Absence of Cyp26b1, a retinoic-acid-degrading enzyme, results in aberrant epidermal differentiation and filaggrin expression, defective cornified envelopes and skin barrier formation, in conjunction with peridermal retention. PMID: 22366455
11. Cyp26b1 regulates retinoic acid signaling in spinal cord progenitor cell populations. PMID: 22214285
12. promotes limb skeletogenesis by inhibiting chondrogenesis PMID: 21807937
13. It was concluded that Cyp26b1 is expressed in the postnatal mouse ovary, regulated by activin, and involved in the control of granulosa cell proliferation. PMID: 21084447
14. role for CYP26B1 in regulating RA-dependent signals in activated T cells but not during TGF-beta-dependent differentiation to Foxp3+ regulatory T cells. PMID: 21249211
15. SHH promotes distal progression of limb development by enhancing CYP26B1-mediated RA clearance as part of a signalling network linking the SHH/GREM1/AER-FGF feedback loop to the newly identified AER-FGF/CYP26B1/RA module. PMID: 21471156
16. data provide genetic evidence to clarify the roles of both RA and CYP26B1 in limb outgrowth and proximo-distal patterning PMID: 20043900
17. CYP26B1 in Sertoli cells acts as a masculinizing factor to arrest male germ cells in the G0 phase of the cell cycle and prevents them from entering meiosis PMID: 19838304
18. Differential expression of the retinoic acid-metabolizing enzymes CYP26A1 and CYP26B1 during murine organogenesis. PMID: 11744378
19. meiosis is retarded in the fetal testis by the action of the retinoid-degrading enzyme CYP26B1, ultimately leading to spermatogenesis PMID: 16574820
20. CYP26B1 maintains low levels of retinoic acid in the developing testes that blocks entry into meiosis and acts as a survival factor to prevent apoptosis of male germ cells. PMID: 17584971
21. Cyp26b1 transcripts and CYP26b1 protein did not change significantly during mouse postnatal testis development. PMID: 18478160
22. Cyp26b1 is expressed within osteoblast cells, demonstrating that retinoic acid levels within these cells need to be tightly controlled PMID: 18927155
23. cyp26b1 mutants may serve as a model to study the etiology of human vertebral disorders such as Klippel-Feil anomaly PMID: 18927157
24. different periods of sensitivity of anterior and posterior hindbrain neural crest derivatives to elevated levels of retinoic acid in the absence of CYP26B1 PMID: 19235731
25. Fluconazole exposure was associated with an up-regulation of CYP26b1 in mouse embryos. PMID: 19429397

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KEGG: mmu:232174

STRING: 10090.ENSMUSP00000076886

UniGene: Mm.255246