Cyp2d4 Antibody

Code CSB-PA714505XA01RA
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Product Details

Full Product Name
Rabbit anti-Rattus norvegicus (Rat) Cyp2d4 Polyclonal antibody
Uniprot No.
Target Names
Cyp2d4
Alternative Names
Cyp2d4 antibody; Cyp2d-18 antibody; Cyp2d-4 antibody; Cyp2d18 antibody; Cytochrome P450 2D4 antibody; EC 1.14.14.1 antibody; CYPIID18 antibody; CYPIID4 antibody; Cytochrome P450 2D-29 antibody; Cytochrome P450 2D-35 antibody; Cytochrome P450 2D18 antibody; Cytochrome P450-CMF3 antibody; Cytochrome P450-DB4 antibody; Debrisoquine 4-hydroxylase antibody
Raised in
Rabbit
Species Reactivity
Rattus norvegicus (Rat)
Immunogen
Recombinant Rattus norvegicus (Rat) Cyp2d4 protein
Immunogen Species
Rattus norvegicus (Rat)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Gene References into Functions
  1. Schizonepetin had significant induction effects on CYP3A1/2 and inhibition effects on CYP1A2, CYP2E1 or CYP2D6 as oriented from the pharmacokinetic profiles of the substrates. PMID: 23235327
  2. Inhibition of brain CYP2D6 results in a lower analgesia response following opiate administration in a pain measurement test. PMID: 23623752
  3. concluded that a novel transcriptional regulatory element NERE specifically regulates the expression of the CYP2D4 PMID: 12818430
  4. results support the idea that cytochrome p450 CYP2D4, not P450c21, works as steroid 21-hydroxylase in the brain PMID: 14563706
Subcellular Location
Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Protein Families
Cytochrome P450 family
Tissue Specificity
Brain.
Database Links
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Call us
301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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