Cyp2f2 Antibody

Code CSB-PA545619XA01MO
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Product Details

Full Product Name
Rabbit anti-Mus musculus (Mouse) Cyp2f2 Polyclonal antibody
Uniprot No.
Target Names
Cyp2f2
Alternative Names
Cyp2f2 antibody; Cyp2f-2Cytochrome P450 2F2 antibody; EC 1.14.14.- antibody; CYPIIF2 antibody; Cytochrome P450-NAH-2 antibody; Naphthalene dehydrogenase antibody; Naphthalene hydroxylase antibody
Raised in
Rabbit
Species Reactivity
Mus musculus (Mouse)
Immunogen
Recombinant Mus musculus (Mouse) Cyp2f2 protein
Immunogen Species
Mus musculus (Mouse)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Involved in the regio- and stereoselective transformation of naphthalene to trans-1R-hydroxy-2R-glutathionyl-1,2-dihydronaphthalene in the presence of glutathione and glutathione S-transferases. It specifically catalyzes the production of a very reactive and potentially toxic intermediate, the 2R,2S arene oxide, that is associated with necrosis of the unciliated bronchiolar epithelial cells or Clara cells in lung.
Gene References into Functions
  1. The P450 2F2 is responsible for the metabolic activation of styrene and plays an important role in styrene-induced pulmonary toxicity. PMID: 24320693
  2. After secondary exposure to naphtalene (NA)female mice had decreased gene/protein expression of CYP2F2 and glutamate-cysteine ligase than NA-tolerant males at all airway levels examined. PMID: 22003090
  3. It is unlikely several chemicals that cause mouse lung tumors via CYP2F2 metabolism will cause lung tumors in humans PMID: 19589367
Subcellular Location
Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Protein Families
Cytochrome P450 family
Tissue Specificity
Clara cells in lung and liver.
Database Links
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Call us
301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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