cpxP Antibody

Code CSB-PA365106XA01ENV
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Product Details

Full Product Name
Rabbit anti-Escherichia coli (strain K12) cpxP Polyclonal antibody
Uniprot No.
Target Names
cpxP
Alternative Names
cpxP antibody; yiiO antibody; b4484 antibody; JW5558Periplasmic protein CpxP antibody; ORF_o167 antibody; Periplasmic accessory protein CpxP antibody
Raised in
Rabbit
Species Reactivity
Escherichia coli (strain K12)
Immunogen
Recombinant Escherichia coli (strain K12) cpxP protein
Immunogen Species
Escherichia coli (strain K12)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Acts as an auxiliary protein in the Cpx two-component envelope stress response system, helping modulate the Cpx response systems response to some inducers. Binds the periplasmic domain of sensor histidine kinase CpxA, inhibiting induction of the Cpx envelope stress response in the absence of inducer; overexpression decreases Cpx pathway activity. Some periplasmic stimulii (shown for P pili subunit PapE and probably 0.3 M NaCl) increase CpxP's susceptibility to DegP, leading to CpxP degradation, inducing the Cpx pathway. Aids in combating extracytoplasmic protein-mediated toxicity. Overexpression leads to degradation by DegP of misfolded P pili subunits in the periplasm (tested using PapE). Inhibits autophosphorylation of CpxA in reconstituted liposomes by 50% but has no effect on phosphatase activity of CpxA. Has mild protein chaperone activity.
Gene References into Functions
  1. The Cpx-TCS within the complex regulatory network in the E. coli response to aminoglycoside-caused stress. PMID: 28923010
  2. We determined that K298 of RNA polymerase alpha is specifically required for glucose-induced cpxP transcription. PMID: 21696463
  3. periplasmic expression could be inhibited by sequence elements in the early coding signal sequence region of cpxP PMID: 17905837
Subcellular Location
Periplasm.
Protein Families
CpxP/Spy family
Database Links
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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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