crb Antibody

1. Results demonstrate that the apical membrane localization of Crumbs is promoted by Dlg5. PMID: 27211898
2. Several Crb mutant proteins accumulated abnormally in the rhabdomere and affected rhodopsin trafficking, suggesting that abnormal rhodopsin physiology contributes to Crb/CRB1-associated retinal degeneration. PMID: 28515229
3. The regulation of Crumbs by Neur is not strictly essential, it contributes to epithelium remodeling in the posterior midgut and thereby facilitates the trans-epithelial migration of the primordial germ cells in early embryos. PMID: 28400441
4. The data provide a molecular basis to explain how the apical determinant Crb can regulate homeostasis of epithelial cells by stabilising Notch at the apical membrane, thereby finetuning Notch pathway activity. PMID: 27899511
5. Data presented here point to a critical role of Crumbs in regulating actomyosin dynamics, cell junctions and morphogenesis. PMID: 26544546
6. The Crumbs:Par-6 crystal structure reveals specific PDZ-peptide contacts that contribute to its higher affinity. PMID: 26894406
7. regulation of Crumbs alternative splicing by the Obelus helicase modulates epithelial polarity during development PMID: 26644515
8. RNKR motif in Crumbs mediates interaction with Sar1 and contributes to efficient ER export. PMID: 25753515
9. phosphorylation-regulated interaction between the cytoplasmic tail of cell polarity protein crumbs and the actin-binding protein moesin PMID: 25792740
10. Crumbs localisation in the principal cells of the hindgut depends on Stardust. In contrast, localisation of Crumbs in the boundary cells does not require Stardust and is independent of its PDZ domain- and FERM-domain binding motifs. PMID: 24710316
11. As well as repressing Yki by recruiting Ex to the apical membrane, Crb promotes phosphorylation-dependent ubiquitin-mediated degradation of Ex. PMID: 24778256
12. The structure function analysis identified intracellular domain of Crb to be required for Abeta42-mediated-neurodegeneration. PMID: 24260128
13. role in cell apical polarity and cell shape stabilisation PMID: 23525000
14. The data demonstrate that the function of crb in photoreceptor development and homeostasis is conserved in compound eyes and ocelli and underscores the evolutionarily relationship between these visual sense organs of Drosophila. PMID: 22608020
15. The only crucial function of Patj hinges on the ability of its first two domains to positively regulate the Crumbs complex, defining a new developmental level of regulation of its dynamics. PMID: 23136386
16. an anisotropic plasma membrane distribution of Crumbs, mediated by its extracellular domain, determines the subcellular localization of a supracellular actomyosin cable at the placode border, with myosin II accumulating at edges where Crumbs is lowest PMID: 23153493
17. Data suggest that Crumbs (Crb) may be part of a "surveillance mechanism" that is responsible for the cell death. PMID: 22683826
18. Positive feedback and mutual antagonism combine to polarize Crumbs in the Drosophila follicle cell epithelium. PMID: 22658591
19. Crb complex and Par proteins are critical during photoreceptor morphogenesis. PMID: 22025631
20. controls epithelial integrity by inhibiting Rac1 and PI3K PMID: 21984807
21. Crb protects against degeneration by interacting with and stabilizing MyoV, thereby ensuring correct rhodopsin 1 trafficking. PMID: 22105348
22. In the absence of retromer, Crb was mis-targeted into lysosomes and degraded, causing a disruption of the apical-basal polarity. PMID: 21958744
23. Regulated Crb accumulation controls apical constriction and invagination in tracheal cells. PMID: 21172808
24. Crumbs overexpression leads to mislocalization of Expanded away from the apical cortex, which is predicted to deregulate the pathway. PMID: 20362447
25. identify the transmembrane protein Crumbs (Crb), a determinant of epithelial apical-basal polarity in Drosophila embryos, as an upstream component of the Hippo pathway in imaginal disk growth control. PMID: 20498073
26. show that Drosophila melanogaster Crumbs, a transmembrane protein controlling cell polarity and morphogenesis, is synthesized with an 83 residues-long signal sequence. PMID: 20189678
27. crb function is not required for maintaining epithelial integrity during the morphogenesis of the head and eye. PMID: 20110329
28. Interacts with Stardust to control polarity of epithelia but not neuroblasts. PMID: 11740559
29. Isolation of Crb1, a mouse homologue of Drosophila crumbs, and analysis of its expression pattern in eye and brain. PMID: 11744384
30. control the position and integrity of the photoreceptor adherens junction and photosensitive organ, or rhabdomere PMID: 11850624
31. apical transmembrane protein Crumbs is a central regulator of epithelial apical-basal polarity in Drosophila; central component of a molecular scaffold that controls zonula adherens assembly and defines the stalk as an apical membrane subdomain PMID: 11850625
32. mutations in Drosophila crumbs result in progressive, light-induced retinal degeneration PMID: 12361571
33. crb plays a role in salivary tube development in Drosophila PMID: 12526813
34. crumbs has a role in regulating epithelial cell polarity in Drosophila along with DaPKC PMID: 15302858
35. Analysis of yurt crb double mutants suggests that these genes function in one pathway and that yurt negatively regulates crb. PMID: 16950127
36. study reports that Lin-7, a scaffolding protein with one Lin-2/Lin-7 domain & one PSD-95/Dlg/ZO-1 domain, is associated with the Crumbs complex in subapical region of embryonic & follicle epithelia & at the stalk membrane of adult photoreceptor cells PMID: 18177979
37. Dynein-mediated messenger RNA transport coupled with a localized translation mechanism is involved in localizing Crb to the apical domain to mediate epithelial apicobasal polarity PMID: 18195099
38. Study shows that the absence of zygotic function of Rho1 results in the selective loss of the apical proteins, Crumbs, Drosophila atypical PKC and Stardust during gland invagination and that this is due to reduced crb RNA levels and apical localization. PMID: 18585373

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KEGG: dme:Dmel_CG6383

STRING: 7227.FBpp0293268

UniGene: Dm.2365