CRYGC Antibody

Code CSB-PA006019XA01HU
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) CRYGC Polyclonal antibody
Uniprot No.
Target Names
CRYGC
Alternative Names
CATARACT; VARIABLE ZONULAR PULVERULENT antibody; CCL antibody; CRGC_HUMAN antibody; CRYG 3 antibody; Cryg 5 antibody; Cryg antibody; CRYG3 antibody; CRYGC antibody; Crystallin gamma 3 antibody; Crystallin gamma C antibody; Gamma C crystallin antibody; Gamma crystallin 2 1 antibody; Gamma crystallin 3 antibody; Gamma crystallin C antibody; Gamma-C-crystallin antibody; Gamma-crystallin 2-1 antibody; Gamma-crystallin 3 antibody; Gamma-crystallin C antibody; Gammab cry antibody; Len antibody
Raised in
Rabbit
Species Reactivity
Homo sapiens (Human)
Immunogen
Recombinant Homo sapiens (Human) CRYGC protein
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Protein A/G
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Crystallins are the dominant structural components of the vertebrate eye lens.
Gene References into Functions
  1. Study identified eight different mutations in CRYGC associated with autosomal dominant congenital nuclear cataracts (ADCC) in a cohort of Chinese family and shows that CRYGC mutations are responsible for 4.1% of ADCC families in the cohort. The results expand the spectrum of CRYGC mutations as well as their associated phenotypes. PMID: 28298635
  2. the G129C mutation in gammaC-crystallin, which is associated with autosomal dominant congenital nuclear cataract, perturbed the unfolding process by promoting the accumulation of two distinct aggregation-prone intermediates under mild denaturing conditions. PMID: 26165230
  3. Exome sequencing in developmental eye disease leads to identification of causal variants in GJA8, CRYGC, PAX6 and CYP1B1. PMID: 24281366
  4. We confirm that congenital cataract is associated with a CRYGC gene mutation. PMID: 23954869
  5. identified a CRYAA mutation in family A and a CRYGC mutation in family B with congenital cataract PMID: 23441109
  6. A nonsense mutation c.471G>A in CRYGC is associated with autosomal dominant congenital nuclear cataracts and microcornea in a Chinese pedigree. PMID: 22876111
  7. Molecular modeling and spectroscopic studies indicated that the mutation impaired the tertiary structure of gamma C crystallin by modifying the H-bonding network in the C-terminal domain. PMID: 22052681
  8. Transgenic expression of mutant CRYGC5bpd gamma-crystallin at near-physiological levels causes lens opacities and fiber cell defects, confirming the pathogenicity of this mutation. PMID: 21436266
  9. The T5P mutation obviously changes conformation and decreases conformational stability. PMID: 11904153
  10. the loss of interactions of T5P mutant of the gammaC-crystallin with other crystallins may play a larger role than the protection afforded by chaperone-like activity in Coppock-like cataract. PMID: 15322286
  11. This is the first case of phenotypic heterogeneity in the primary congenital cataract specifically associated with the R168W mutation in the CRYGC gene. PMID: 17679936
  12. Identification of a novel nonsense mutation in CRYGC in a Chinese family with autosomal dominant congenital nuclear cataracts and microcornea. PMID: 19204787

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Involvement in disease
Cataract 2, multiple types (CTRCT2)
Protein Families
Beta/gamma-crystallin family
Database Links

HGNC: 2410

OMIM: 123680

KEGG: hsa:1420

STRING: 9606.ENSP00000282141

UniGene: Hs.72910

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