crm Antibody

Code CSB-PA529239XA01DLU
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Product Details

Full Product Name
Rabbit anti-Drosophila melanogaster (Fruit fly) crm Polyclonal antibody
Uniprot No.
Target Names
crm
Alternative Names
crm antibody; CG2714Protein cramped antibody
Raised in
Rabbit
Species Reactivity
Drosophila melanogaster (Fruit fly)
Immunogen
Recombinant Drosophila melanogaster (Fruit fly) crm protein
Immunogen Species
Drosophila melanogaster (Fruit fly)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)
Usage
For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function
Polycomb group (Pc-G) genes are needed to maintain expression patterns of the homeotic selector genes of the Antennapedia (Antp-C) and Bithorax (Bx-C) complexes, and hence for the maintenance of segmental determination. Can act as a modifier of position effect variegation (PEV).
Gene References into Functions
  1. CRM is specifically required for the expression of the Histone H1 gene. PMID: 21336627
  2. crm modulates the effect of temperature on a genomic region encoding Hedgehog and Wingless signaling effectors. PMID: 21283785
Subcellular Location
Nucleus. Note=During S-phase in early embryogenesis. Colocalizes with PCNA in polytene nuclei during embryogenesis.
Protein Families
Cramped family
Tissue Specificity
Ubiquitously expressed throughout embryonic development. High expression is detected in CNS and gonads.
Database Links

KEGG: dme:Dmel_CG2714

STRING: 7227.FBpp0070472

UniGene: Dm.68

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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