crp Antibody

1. TopoI is required for the Mycobacterium tuberculosis growth. PMID: 24593153
2. Mycobacterium tuberculosis cAMP receptor protein can function as a classical transcription factor in M. tuberculosis, though this occurs at only a subset of cAMP receptor protein binding sites. PMID: 24957601
3. Data show that M. tuberculosis cAMP receptor protein (CRP) has evolved several distinct characteristics, compared with the Escherichia coli CRP paradigm, to allow it to regulate gene expression against a background of high concentrations of cAMP. PMID: 20028978
4. Rv3676 is a direct regulator of rpfA expression, and because rpfA codes for a resuscitation promoting factor this may implicate Rv3676 in reactivation of dormant M. tuberculosis infections. PMID: 15882420
5. These results provide the first direct evidence for cAMP binding to a transcription factor in M. tuberculosis, suggesting a role for cAMP signal transduction in M. tuberculosis and implicating CRP(Mt) as a cAMP-responsive global regulator. PMID: 16267303
6. The CRP/FNR family transcription factor from M. tuberculosis H37Rv has been crystallized; the structure of the protein might provide insight into transcriptional regulation in the pathogen by this protein. PMID: 16946467
7. At 6-10 microM concentrations of cAMP Rv3676 shows positive cooperativity; at 10 microM cAMP the protein exists in the most open conformation. Rv3676 could bind specifically to the putative CRP/FNR nucleotide sequence elements. PMID: 17702648
8. Comparison of the structures of apo MtbCRP and DNA-bound EcCRP shows how DNA binding would be inhibited in the absence of cAMP and supports a mechanism involving functional asymmetry in apoCRP. PMID: 19193643
9. Structural insights into the mechanism of the allosteric transitions of Mycobacterium tuberculosis cAMP receptor protein. PMID: 19740754

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KEGG: mtu:Rv3676

STRING: 83332.Rv3676