crtc-1 Antibody

Code CSB-PA172399XA01CXY
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Product Details

Full Product Name
Rabbit anti-Caenorhabditis elegans crtc-1 Polyclonal antibody
Uniprot No.
Target Names
crtc-1
Alternative Names
crtc-1 antibody; Y20F4.2CREB-regulated transcription coactivator 1 homolog antibody
Raised in
Rabbit
Species Reactivity
Caenorhabditis elegans
Immunogen
Recombinant Caenorhabditis elegans crtc-1 protein
Immunogen Species
Caenorhabditis elegans
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Transcriptional coactivator for crh-1, the homolog of vertebrate transcription factor CREB1. Regulates the transcription of metabolic genes and may have a role in mitochondrial dynamics and metabolism. Through crh-1, counteracts the pro-lifespan-extension signals of AMPK both cell autonomously and, when expressed in neurons, at a systemic level, possibly using the catecholamine analog, octopamine, as a messenger.
Gene References into Functions
  1. Study shows that CRTC-1 specifically uncouples AMPK/calcineurin-mediated effects on lifespan from pleiotropic side effects by reprogramming mitochondrial and metabolic function. This pro-longevity metabolic state is regulated cell nonautonomously by CRTC-1 in the nervous system. PMID: 25723162
Subcellular Location
Nucleus. Cytoplasm, cytosol.
Protein Families
TORC family
Tissue Specificity
Expressed throughout the intestine and in head and tail neurons. Expressed in octopaminergic RIC neurons.
Database Links

KEGG: cel:CELE_Y20F4.2

STRING: 6239.Y20F4.2

UniGene: Cel.20318

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