csp-1 Antibody

Code CSB-PA136494XA01CXY
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Product Details

Full Product Name
Rabbit anti-Caenorhabditis elegans csp-1 Polyclonal antibody
Uniprot No.
Target Names
csp-1
Alternative Names
csp-1 antibody; Y48E1B.13Caspase A antibody; EC 3.4.22.36) [Cleaved into: Caspase A subunit p16; Caspase A subunit p14] antibody
Raised in
Rabbit
Species Reactivity
Caenorhabditis elegans
Immunogen
Recombinant Caenorhabditis elegans csp-1 protein
Immunogen Species
Caenorhabditis elegans
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Cysteine protease which, in vitro, cleaves itself and caspase ced-3 into their mature active forms. Also cleaves, in vitro, inactive caspase csp-2 isoform b. Required maternally to induce apoptosis in a subset of cells fated to die during embryogenesis, mostly independently of the ced-9, ced-4 and ced-3 canonical apoptosis pathway. Involved in the degeneration of dopaminergic CEP neurons in response to high Mn(2+) levels.; Dispensable for regulating apoptosis during embryogenesis.
Gene References into Functions
  1. CSP-1 is a pro-apoptotic caspase that promotes programmed cell death in a subset of cells fated to die during C. elegans embryogenesis. PMID: 23505386
Protein Families
Peptidase C14A family
Tissue Specificity
Isoform a: Expression is restricted to the late germline pachytene stage of meiosis I in both L4 larvae and adult hermaphrodite gonads. Isoform b: Expression is restricted to the late germline pachytene stage of meiosis I in both L4 larvae and adult herma
Database Links
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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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