Product Details

Full Product Name

Rabbit anti-Arabidopsis thaliana (Mouse-ear cress) CTF7 Polyclonal antibody

Uniprot No.

A7UL74

Target Names

CTF7

Alternative Names

CTF7 antibody; ECO1 antibody; At4g31400 antibody; F3L17.7 antibody; Protein CHROMOSOME TRANSMISSION FIDELITY 7 antibody; EC 2.3.1.- antibody; Cohesion establishment factor CTF7 antibody; Protein ESTABLISHMENT OF COHESION 1 antibody

Raised in

Rabbit

Species Reactivity

Arabidopsis thaliana

Immunogen

Recombinant Arabidopsis thaliana CTF7 protein

Immunogen Species

Arabidopsis thaliana (Mouse-ear cress)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Target Background

Function

Acetyltransferase required for the establishment of sister chromatid cohesion. Involved in preservation of genome integrity and meiosis. Required for DNA repair and for the regulation of chromosome segregation during mitotic cell division. Knock-down mutants are extremely dwarf. Regulator of sister chromatid cohesion in meiosis which negatively regulates cohesin association with chromatin, acting as an antagonist of WAPL1 and WAPL2.

Gene References into Functions

affects cytosine methylation, especially symmetric CG methylation, and expression of the copia28 retrotransposon PMID: 26039473
High level expression of AtCTF7 mutant proteins disrupts megasporogenesis, megagametogenesis and male meiosis, as well as causing a broad range of vegetative defects, including dwarfism that are inherited in a non-Mendelian fashion. PMID: 25848842
we show that mutations in AtWAPL suppress the lethality associated with inactivation of AtCTF7 PMID: 25033056
Arabidopsis CTF7/ECO1 plays important roles in the preservation of genome integrity and meiosis. PMID: 23750584
CTF7 is required for establishment of sister chromatid cohesion and association of cohesin with chromatin during meiosis. PMID: 23941555
Seeds containing T-DNA insertions in CTF7 exhibit embryo lethality early in development, while the endosperm develops normally. Overexpression of CTF7 blocked female gametophyte development. PMID: 20671110

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Subcellular Location

Nucleus. Cytoplasm.

Protein Families

Acetyltransferase family, ECO subfamily

Tissue Specificity

Expressed in roots, stems, leaves, young seedlings and flower buds. Detected in the embryo, but not in the endosperm.

Database Links

KEGG: ath:AT4G31400

STRING: 3702.AT4G31400.1

UniGene: At.50388

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CTF7 Antibody

Product Details

Customer Reviews and Q&A

Target Background