COB Antibody

Datasheet

Code	CSB-PA015075XA01SVG
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Target Background

Product Details

Full Product Name

Rabbit anti-Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) COB Polyclonal antibody

Uniprot No.

P00163

Target Names

COB

Alternative Names

COB antibody; CYTB antibody; Q0105 antibody; Cytochrome b antibody; EC 7.1.1.8 antibody; Complex III subunit 3 antibody; Complex III subunit CYTB antibody; Complex III subunit III antibody; Cytochrome b-c1 complex subunit 3 antibody; Cytochrome b-c1 complex subunit CYTB antibody; Ubiquinol-cytochrome c oxidoreductase complex cytochrome b subunit antibody

Raised in

Rabbit

Species Reactivity

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Immunogen

Recombinant Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) COB protein

Immunogen Species

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

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Target Background

Function

Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c. Cytochrome b is a catalytic core subunit containing 2 b-type hemes BL and BH topographically segregated in the quinone reduction (Qi) and quinol oxidation (Q0) sites on opposite sides of the membrane.

Gene References into Functions

Here, we unravel the sequence of events in the mitochondrial inner membrane by which cytochrome b is hemylated. PMID: 24841564
Altered kinetics at center N (where uiquinone is re-reduced) and activation of ubiquinol oxidation by binding of cytochrome c in the mutant Tyr132Phe and Glu272Asp enzymes indicate long range effects of these mutations. PMID: 17145759
E272 residue may not be involved in direct substrate binding or in its direct deprotonation. PMID: 18215069
there is a pathway for structural communication between the two active sites of cytochrome b and open new possibilities for the utilization of center N as a potential drug target. PMID: 19179332
Ccm1p/Ygr150cp is essential to remove the fourth intron of COB pre-mRNAs in Saccharomyces cerevisiae. PMID: 19562342

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Subcellular Location

Mitochondrion inner membrane; Multi-pass membrane protein.

Protein Families

Cytochrome b family

Database Links

KEGG: sce:Q0105

STRING: 4932.Q0105

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Email: [email protected]
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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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COB Antibody

Product Details

Related Products

Customer Reviews and Q&A

Target Background