Product Details

Full Product Name

Rabbit anti-Drosophila melanogaster (Fruit fly) CycG Polyclonal antibody

Uniprot No.

Q95TJ9

Target Names

CycG

Alternative Names

CycG antibody; CG11525Cyclin G antibody

Raised in

Rabbit

Species Reactivity

Drosophila melanogaster (Fruit fly)

Immunogen

Recombinant Drosophila melanogaster (Fruit fly) CycG protein

Immunogen Species

Drosophila melanogaster (Fruit fly)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Target Background

Function

Cyclin with roles in multiple processes including transcription, meiotic recombination repair, cell cycle regulation, and promotion of normal growth and metabolism. Binds to the promoter region of the homeobox gene Abd-B and is involved in maintaining Abd-B expression in the pupal epithelium. Involved in the transcriptional repression of the homeotic genes Scr and Ubx. Plays a role in meiotic recombination repair of DNA double-strand breaks which ensures efficient translation of grk and promotes grk activity in the oocyte, leading to oocyte dorso-ventral axis formation following secretion of grk from the oocyte and its binding to Egfr in the directly overlying follicle cells. Negatively regulates the binding of serine/threonine-protein kinase Akt1 to the protein phosphatase 2A subunit wdb, promoting normal growth and metabolism. Required for the formation of bilateral symmetry. Negatively regulates cell cycle progression by preventing G1 to S transition and retarding S-phase progression.

Gene References into Functions

Loss of CycG modified dominant wing phenotypes of Notch, Delta and Hairless mutants. Whereas Notch loss of function phenotype was ameliorated by a loss of CycG, phenotypes of Notch gain of function or of Delta or Hairless loss of function were enhanced PMID: 26963612
CycG acts at the level of Akt1 to regulate growth and metabolism via PP2A in Drosophila. PMID: 26274446
CycG promotes Gurken-mediated activation of EGFR signalling. PMID: 23121330
CycG has a role in an early step of meiotic recombination repair. PMID: 22976300
Our results highlight the role of CycG in the control of developmental stability in D. melanogaster PMID: 21998598
Cyclin G is encoded by an essential gene, since either RNAi-disruption or cDNA overexpression resulted in high lethality. PMID: 21441780
Overproduction of Cyclin G produces small cells whereas shortage produces large cells, suggesting that Cyclin G negatively regulates cell growth. PMID: 21311225

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Subcellular Location

Chromosome.

Protein Families

Cyclin family, Cyclin G subfamily

Database Links

KEGG: dme:Dmel_CG11525

STRING: 7227.FBpp0305520

UniGene: Dm.1390

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CycG Antibody

Product Details

Customer Reviews and Q&A

Target Background