Cr1l Antibody

Code CSB-PA717575ZA01MO
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Product Details

Full Product Name
Rabbit anti-Mus musculus (Mouse) Cr1l Polyclonal antibody
Uniprot No.
Target Names
Alternative Names
Cr1l antibody; Crry antibody; CryComplement component receptor 1-like protein antibody; Complement regulatory protein Crry antibody; Protein p65 antibody
Raised in
Species Reactivity
Mus musculus
Recombinant Mus musculus Cr1l protein
Immunogen Species
Mus musculus (Mouse)
Purification Method
Protein A/G
It differs from different batches. Please contact us to confirm it.
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Tested Applications
ELISA, WB (ensure identification of antigen)
Troubleshooting and FAQs
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (12-14 weeks)

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Target Background

Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. Also acts as a decay-accelerating factor, preventing the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade. Plays a crucial role in early embryonic development by maintaining fetomaternal tolerance. Also acts as a costimulatory factor for T-cells which favors IL-4 secretion.
Gene References into Functions
  1. CRRY role in the retinal epithelium and photoreceptor degeneration PMID: 28348233
  2. this study has provided direct evidence for a role of Crry in controlling spontaneous alternative pathway complement activation on renal tubular epithelial cells. PMID: 24850152
  3. Crry costimulation enhanced the in vitro expansion of natural Treg cells while maintaining their phenotypic and suppressive properties. Crry-expanded Treg cells decreasing antigen-dependent secretion of cytokines. PMID: 21380996
  4. Stmn2 and the chromosome 14 Rarb region, but not Cr1 or Clu or Picalm, have roles in prion disease. PMID: 21151910
  5. Crry is clearly present in the placentas from spontaneous abortions in mice. PMID: 20484840
  6. Crry is the only membrane-bound complement regulator expressed on the basolateral surface of murine renal tubular epithelial cells under in vitro culture conditions. PMID: 20675597
  7. Data show that a single-nucleotide polymorphism in the first short consensus repeat of Sle1c Crry introduced a novel N-linked glycosylation site likely responsible for structural alteration. PMID: 20660348
  8. mesangial cell Crry limits complement activation and subsequent neutrophil recruitment in the setting of local immune complex deposition. PMID: 19740350
  9. Long-term complement blockade with Crry, a C3 convertase inhibitor overexpressed in a transgenic mouse line, reduces renal disease and improves survival in lupus-prone MRL/lpr mice. PMID: 11907125
  10. the role of crry in regulating complement regulation PMID: 11915940
  11. Crry is indispensable for erythrocyte protection from spontaneous complement attack PMID: 11986227
  12. Crry plays a more dominant role than DAF in regulating the alternative pathway of complement C3 activation, whereas DAF and Crry are equally effective in preventing antibody-induced runaway complement activation. PMID: 12393518
  13. X-ray and neutron scattering was performed on recombinant rat Crry containing the first five SCR domains (rCrry) and mouse Crry with five SCR domains conjugated to the Fc fragment of mouse IgG1 (mCrry-Ig) PMID: 12767833
  14. Mice transgenic for murine complement inhibitor Crry are largely protected from developing collagen-induced arthritis. PMID: 12902517
  15. Data demonstrate that transgenic mice with astrocyte-targeted expression of the soluble complement inhibitor sCrry have a significantly reduced neurologic impairment and improved blood-brain barrier function after closed head injury. PMID: 12973023
  16. The dual function of Crry as a complement regulatory protein and as a T cell costimulator illustrates the importance of complement regulatory proteins as links between innate and adaptive immunity. PMID: 16301324
  17. Results suggest that altered expression of Crry within the tubular epithelium appears to be a critical factor permitting activation of the alternative pathway of complement after ischemia/reperfusion. PMID: 16444293
  18. both a high level expression and a more potent anti-alternative pathway complement activity of Crry contributed to its indispensable role on murine erythrocytes PMID: 17015743
  19. Our data suggest complement provides some protection of mature oligodendrocytes during cuprizone treatment but may be critical for subsequent remyelination events. PMID: 17674370
  20. DAF and Crry double deficiency led to rapid clearance of platelets from circulation in a complement- and macrophage-dependent manner; redundant role of DAF and Crry in platelet survival PMID: 18524992
  21. Membrane complement regulator Crry helps to maintain homeostasis of the complement alternative pathway (AP) and demonstrates that Crry-deficient mice can be rescued on a partial as well as on a complete factor B- or C3-deficient maternal background. PMID: 18684964
  22. Pak1 is an essential molecular target for modulating acute mast cell responses that contribute to allergic diseases. PMID: 19124833
  23. Crry is essential for mature T-cell survival in the periphery but not for lymphogenesis in the thymus. PMID: 19136662
  24. Crry and CD59 are critical in protecting Treg cells from complement mediated injuries. PMID: 19281793

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Subcellular Location
Membrane; Single-pass type I membrane protein.
Protein Families
Receptors of complement activation (RCA) family
Tissue Specificity
Ubiquitously expressed (at protein level).
Database Links

KEGG: mmu:12946

UniGene: Mm.301652

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