Recombinant Mouse Complement component receptor 1-like protein (Cr1l), partial

In Stock
Code CSB-EP717575MO1
MSDS
Size US$306
Order now
Image
  • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP717575MO1 could indicate that this peptide derived from E.coli-expressed Mus musculus (Mouse) Cr1l.
  • Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP717575MO1 could indicate that this peptide derived from E.coli-expressed Mus musculus (Mouse) Cr1l.
Have Questions? Leave a Message or Start an on-line Chat

Product Details

Purity
Greater than 85% as determined by SDS-PAGE.
Target Names
Cr1l
Uniprot No.
Research Area
others
Alternative Names
Cr1l; Crry; CryComplement component receptor 1-like protein; Complement regulatory protein Crry; Protein p65
Species
Mus musculus (Mouse)
Source
E.coli
Expression Region
41-405aa
Target Protein Sequence
ELRGGLGKHGHTVHREPAVNRLCADSKRWSGLPVSAQRPFPMGHCPAPSQLPSAKPINLTDESMFPIGTYLLYECLPGYIKRQFSITCKQDSTWTSAEDKCIRKQCKTPSDPENGLVHVHTGIQFGSRINYTCNQGYRLIGSSSAVCVITDQSVDWDTEAPICEWIPCEIPPGIPNGDFFSSTREDFHYGMVVTYRCNTDARGKALFNLVGEPSLYCTSNDGEIGVWSGPPPQCIELNKCTPPPYVENAVMLSENRSLFSLRDIVEFRCHPGFIMKGASSVHCQSLNKWEPELPSCFKGVICRLPQEMSGFQKGLGMKKEYYYGENVTLECEDGYTLEGSSQSQCQSDGSWNPLLAKCVSRSISG
Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
Mol. Weight
44.5 kDa
Protein Length
Partial
Tag Info
N-terminal 6xHis-tagged
Form
Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer
If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
Note: If you have any special requirement for the glycerol content, please remark when you place the order.
If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
3-7 business days
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA
Please contact us to get it.

Customer Reviews and Q&A

 Customer Reviews

There are currently no reviews for this product.

Submit a Review here

Target Background

Function
Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. Also acts as a decay-accelerating factor, preventing the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade. Plays a crucial role in early embryonic development by maintaining fetomaternal tolerance. Also acts as a costimulatory factor for T-cells which favors IL-4 secretion.
Gene References into Functions
  1. CRRY role in the retinal epithelium and photoreceptor degeneration PMID: 28348233
  2. this study has provided direct evidence for a role of Crry in controlling spontaneous alternative pathway complement activation on renal tubular epithelial cells. PMID: 24850152
  3. Crry costimulation enhanced the in vitro expansion of natural Treg cells while maintaining their phenotypic and suppressive properties. Crry-expanded Treg cells decreasing antigen-dependent secretion of cytokines. PMID: 21380996
  4. Stmn2 and the chromosome 14 Rarb region, but not Cr1 or Clu or Picalm, have roles in prion disease. PMID: 21151910
  5. Crry is clearly present in the placentas from spontaneous abortions in mice. PMID: 20484840
  6. Crry is the only membrane-bound complement regulator expressed on the basolateral surface of murine renal tubular epithelial cells under in vitro culture conditions. PMID: 20675597
  7. Data show that a single-nucleotide polymorphism in the first short consensus repeat of Sle1c Crry introduced a novel N-linked glycosylation site likely responsible for structural alteration. PMID: 20660348
  8. mesangial cell Crry limits complement activation and subsequent neutrophil recruitment in the setting of local immune complex deposition. PMID: 19740350
  9. Long-term complement blockade with Crry, a C3 convertase inhibitor overexpressed in a transgenic mouse line, reduces renal disease and improves survival in lupus-prone MRL/lpr mice. PMID: 11907125
  10. the role of crry in regulating complement regulation PMID: 11915940
  11. Crry is indispensable for erythrocyte protection from spontaneous complement attack PMID: 11986227
  12. Crry plays a more dominant role than DAF in regulating the alternative pathway of complement C3 activation, whereas DAF and Crry are equally effective in preventing antibody-induced runaway complement activation. PMID: 12393518
  13. X-ray and neutron scattering was performed on recombinant rat Crry containing the first five SCR domains (rCrry) and mouse Crry with five SCR domains conjugated to the Fc fragment of mouse IgG1 (mCrry-Ig) PMID: 12767833
  14. Mice transgenic for murine complement inhibitor Crry are largely protected from developing collagen-induced arthritis. PMID: 12902517
  15. Data demonstrate that transgenic mice with astrocyte-targeted expression of the soluble complement inhibitor sCrry have a significantly reduced neurologic impairment and improved blood-brain barrier function after closed head injury. PMID: 12973023
  16. The dual function of Crry as a complement regulatory protein and as a T cell costimulator illustrates the importance of complement regulatory proteins as links between innate and adaptive immunity. PMID: 16301324
  17. Results suggest that altered expression of Crry within the tubular epithelium appears to be a critical factor permitting activation of the alternative pathway of complement after ischemia/reperfusion. PMID: 16444293
  18. both a high level expression and a more potent anti-alternative pathway complement activity of Crry contributed to its indispensable role on murine erythrocytes PMID: 17015743
  19. Our data suggest complement provides some protection of mature oligodendrocytes during cuprizone treatment but may be critical for subsequent remyelination events. PMID: 17674370
  20. DAF and Crry double deficiency led to rapid clearance of platelets from circulation in a complement- and macrophage-dependent manner; redundant role of DAF and Crry in platelet survival PMID: 18524992
  21. Membrane complement regulator Crry helps to maintain homeostasis of the complement alternative pathway (AP) and demonstrates that Crry-deficient mice can be rescued on a partial as well as on a complete factor B- or C3-deficient maternal background. PMID: 18684964
  22. Pak1 is an essential molecular target for modulating acute mast cell responses that contribute to allergic diseases. PMID: 19124833
  23. Crry is essential for mature T-cell survival in the periphery but not for lymphogenesis in the thymus. PMID: 19136662
  24. Crry and CD59 are critical in protecting Treg cells from complement mediated injuries. PMID: 19281793

Show More

Hide All

Subcellular Location
Membrane; Single-pass type I membrane protein.
Protein Families
Receptors of complement activation (RCA) family
Tissue Specificity
Ubiquitously expressed (at protein level).
Database Links

KEGG: mmu:12946

UniGene: Mm.301652

icon of phone
Call us
301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
icon of address
Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
icon of social media
Join us with

Subscribe newsletter

Leave a message

* To protect against spam, please pass the CAPTCHA test below.
CAPTCHA verification
© 2007-2024 CUSABIO TECHNOLOGY LLC All rights reserved. 鄂ICP备15011166号-1
Place an order now

I. Product details

*
*
*
*

II. Contact details

*
*

III. Ship To

*
*
*
*
*
*
*

IV. Bill To

*
*
*
*
*
*
*
*