daf-12 Antibody

1. that CYP-37A1 (ortholog of human cytochrome P450 CYP4V2), EMB-8 (ortholog of human P450 oxidoreductase POR), and DAF-12 (homolog of human nuclear receptors VDR/LXR) constitute a hormone synthesis and nuclear receptor pathway in Caenorhabditis elegans. PMID: 28760992
2. Study reports that in addition to its well-studied role in controlling developmental gene expression, the DAF-12 endocrine system governs expression of a gene network that stimulates the aerobic catabolism of fatty acids. Thus, activation of the DAF-12 transcriptome coordinately mobilizes energy stores to permit reproductive growth. PMID: 25774872
3. Under daf-12 RNAi rescue of survival by carnitine was abolished. RNA-interference for gamma-butyrobetaine hydroxylase 2, encoding the key enzyme for carnitine biosynthesis did neither increase glucose toxicity nor prevent the rescue of survival by carnitine PMID: 25817784
4. Endogenous steroids that act as ligands of the C. elegans DAF-12, a vitamin D and liver X receptor homolog regulating larval development, fat metabolism, and lifespan, were identified. PMID: 24411940
5. Caenorhabditis elegans nuclear receptor DAF-12 negatively regulates the defense against pathogens via the downstream let-7 family of microRNAs PMID: 23990780
6. The miRNAs target an early larval nuclear factor lin-14 and akt-1/kinase, thereby stimulating DAF-16/FOXO signaling to extend life. PMID: 23239738
7. these data are consistent with daf-12 acting to ensure developmental robustness by committing the animal to adult or dauer developmental programs PMID: 21814518
8. our findings indicate that in C. elegans lacking germ cells, the somatic reproductive tissues promote longevity via steroid hormone signaling to DAF-12. PMID: 20824162
9. DAF-12, a nuclear hormone receptor, is required for the correct timing of let-7 RNA and let-7:gfp expression. PMID: 12871707
10. The DAF-12 is an orphan nuclear hormone receptor that mediates these developmental decisions and influences adult lifespan. We propose that dauer rescuing activity is a hormone synthesized by DAF-9 that acts through DAF-12. PMID: 15569358
11. R197K substitution led to reduction in regulatory activity correlated with greatly decreased DNA binding affinity in vitro, suggesting a role for the DAF-12 DBD C-terminal region (dbdC), and specifically for Arg(197), in DNA binding PMID: 15611047
12. Daf-12 modulating aging and stress responses in part through the repression of specific genes, and emphasize the role that the repression of genes that curtail maximal lifespan plays in lifespan determination. PMID: 16626392
13. Data show that insulin-like signaling negatively regulates muscle arm extension through DAF-12 in Caenorhabditis elegans. PMID: 18436204
14. DAF-12 acts at a choice point between alternatives favoring reproduction (mate searching) vs. survival (remaining on food. PMID: 18854588
15. findingss show DAF-12 & its steroidal ligand activate promoters of let-7 microRNA family members to downregulate the microRNA target hbl-1, which drives progression of epidermal stem cells from second to third larval stage patterns of cell division PMID: 19342589
16. Studies show that miRNA regulation is directly mediated by ligand occupancy of a nuclear hormone receptor DAF-12 that acts to couple nutrient availability to developmental programs. PMID: 19690329
17. A complex feedback loop between DAF-12 and the let-7-family miRNAs involving both the repression of DAF-12 by let-7-family miRNAs and the ligand-modulated transcriptional activation and repression of the let-7-Fam miRNAs by DAF-12, is reported. PMID: 19828440

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KEGG: cel:CELE_F11A1.3

STRING: 6239.F11A1.3a

UniGene: Cel.18135