danr Antibody

Code CSB-PA895589XA01DLU
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Product Details

Full Product Name
Rabbit anti-Drosophila melanogaster (Fruit fly) danr Polyclonal antibody
Uniprot No.
Target Names
danr
Alternative Names
danr antibody; CG13651Protein distal antenna-related antibody
Raised in
Rabbit
Species Reactivity
Drosophila melanogaster (Fruit fly)
Immunogen
Recombinant Drosophila melanogaster (Fruit fly) danr protein
Immunogen Species
Drosophila melanogaster (Fruit fly)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Probable transcription factor with a role in the retinal determination (RD) network. Regulates ato expression and is required for normal R8 induction and differentiation. Danr appears to repress Dan expression, but Dan is required for Danr expression anterior to the morphogenetic furrow (MF). Dan and Danr lie downstream of so and require dac function for highest levels of expression. Contributes to differentiation of antenna-specific characteristics; effector gene that acts downstream of homothorax (hth), Distal-less (Dll), cut (ct) and spineless (ss) genes to control differentiation of distal antennal structures.
Gene References into Functions
  1. results show that the hernandez and fernandez genes are required for antennal and eye development and are also able to specify eye or antenna ectopically PMID: 12921746
  2. fernandez and hernandez genes are required in the nervous system during the embryonic development PMID: 15162514
  3. Dan and Danr have roles in Drosophila eye development PMID: 17493605
Subcellular Location
Nucleus.
Tissue Specificity
Coexpressed with dan in the presumptive distal antenna, but not in the leg imaginal disk. Both proteins are also expressed in the brain and the eye region of the eye-antenna disk. First detected in early L3 eye disks in cells surrounding the newly initiat
Database Links

KEGG: dme:Dmel_CG13651

STRING: 7227.FBpp0084155

UniGene: Dm.5188

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