dco Antibody

1. we show that spag knock-down or reduced Dbt activity in circadian cells leads to longer circadian periods and expression of activated initiator caspase only during the middle of the day. PMID: 25951229
2. Responses of the clock to light via the regulated translation of DBT. PMID: 25211129
3. Data show that the HSP-90 cochaperone spaghetti protein (SPAG) antagonizes casein kinase I epsilon DBT autophosphorylation in S2 cells PMID: 25939385
4. Data demonstrate that overall reduction of DBT causes long and arrhythmic behavior revealing an unexpected role in promoting synchrony of the circadian clock network. PMID: 24820422
5. The introduction of CKI-epsilon point mutation L39Q, found in human breast cancer, into the fly homolog dco causes an overgrowth phenotype in imaginal disc tissue. Adding S101R, modifies the mutant phenotype so that the affected tissue disintegrates. PMID: 20979026
6. expression of DBT in Drosophila S2 cells produced a CKI-7-sensitive kinase activity which was reduced by both the dbt(S) and dbt(L) mutations of circadian rhythm PMID: 14701759
7. Dco coordinates tissue size by stimulating cell division/growth and blocking apoptosis via activation of DIAP1 expression. PMID: 17134692
8. This first analysis of adult flies with a virtual lack of DBT activity demonstrates that DBT's kinase activity is necessary for normal circadian rhythms and that a general reduction of DBT kinase activity does not produce short periods. PMID: 17893330
9. human casein kinase 1 epsilon cannot replace the activity of dbt in flies despite the high degree of similarity in primary sequence and kinase function PMID: 18258753
10. heterozygous mutations of this gene, which encodes the major catalytic subunit of PKA (cAMP-dependent kinase), delayed AMI onset by more than 2-fold without affecting lifespan and memory at young age.(review) PMID: 18646611
11. The results demonstrate a high degree of evolutionary conservation of fly and vertebrate CKIdelta and of the functions affected by their period-shortening mutations. PMID: 18957703
12. These results suggest that DBT regulates phosphorylation, stability and localization of PDP1epsilon, and that it has multiple targets in the Drosophila circadian system. PMID: 19663814

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KEGG: dme:Dmel_CG2048

STRING: 7227.FBpp0085104

UniGene: Dm.1901