Product Details

Full Product Name

Rabbit anti-Caenorhabditis elegans dcs-1 Polyclonal antibody

Uniprot No.

G5EFS4

Target Names

dcs-1

Alternative Names

dcs-1 antibody; hsl-1 antibody; Y113G7A.9m7GpppX diphosphatase antibody; EC 3.6.1.59 antibody; Decapping scavenger enzyme antibody; Heat shock-like protein antibody; Protein DCS-1 antibody; Scavenger mRNA-decapping enzyme DcpS antibody

Raised in

Rabbit

Species Reactivity

Caenorhabditis elegans

Immunogen

Recombinant Caenorhabditis elegans dcs-1 protein

Immunogen Species

Caenorhabditis elegans

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

Target Background

Function

Decapping scavenger enzyme that catalyzes the cleavage of a residual cap structure following the degradation of mRNAs of the 3'->5' exosome-mediated mRNA decay pathway. Hydrolyzes cap analog structures like 7-methylguanosine nucleoside triphosphate (m7GpppG) and tri-methyl guanosine nucleoside triphosphate (m3(2,2,7)GpppG) with up to 2 nucleotide substrates (small capped oligoribonucleotides) and specifically releases 5'-phosphorylated RNA fragments and 7-methylguanosine monophosphate (m7GMP). Does not hydrolyze unmethylated cap analog (GpppG) and shows no decapping activity on intact m7GpppG-capped mRNA molecules. Does not hydrolyze 7-methylguanosine diphosphate (m7GDP) and tri-methylguanosine diphosphate (m3(2,2,7)GDP) to m(7)GMP and m3(2,2,7)GMP, respectively. May also play a role in the 5'->3 mRNA decay pathway; m7GDP, the downstream product released by the 5'->3' mRNA mediated decapping activity, may be also converted by dcs-1 to m7GMP. Binds to m7GpppG and strongly to m7GDP.

Gene References into Functions

DCS-1 is part of a degradation complex that performs microRNA turnover in animals. PMID: 23541767
The rate dynamics of DcpS on its natural substrates and dinucleotide cap analogs, modified in the nucleoside base or ribose moiety, was examined. PMID: 20546305
dual catalytic activity of DspS as a hydrolase and a phosphorylase was discovered. PMID: 19896942
dsc-1 encodes a Q50 Paired (Prd)-like homeodomain protein which affects the periodicity of defecation, revealing an unanticipated role for the enteric muscles in regulating this ultradian rhythm. PMID: 16236771
DcpS (scavenger decapping enzyme) from nematode C. elegans readily hydrolyzes both monomethyl- and trimethylguanosine cap analogues. PMID: 18066754

Hide All

Subcellular Location

Nucleus.

Protein Families

HIT family

Tissue Specificity

Expressed in neurons in the ventral cord, the nerve ring and the pharynx.

Database Links

KEGG: cel:CELE_Y113G7A.9

STRING: 6239.Y113G7A.9a

UniGene: Cel.1464

Message

Product >> Product Name：
Product >> Code：
Name： *
Email： *
Company/Organization：
Phone：
Since emails may get flagged by spam filters occasionally, we recommend leaving your phone number as a precaution. Your information is safe with us.
Question/Comment： *
Your Region： *
I'd like to receive email newsletters from Cusabio

Yes

No
How do you know CUSABIO?

Email

Distributor

Search engine

Advertisement

Others
CAPTCHA verification：

Code	CSB-PA123525XA01CXY
Size	Enquire
Have Questions?	Leave a Message or Start an on-line Chat

dcs-1 Antibody

Product Details

Customer Reviews and Q&A

Target Background