DCTN1-p150 Antibody

Code CSB-PA006564XA01DLU
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Product Details

Full Product Name
Rabbit anti-Drosophila melanogaster (Fruit fly) DCTN1-p150 Polyclonal antibody
Uniprot No.
Target Names
DCTN1-p150
Alternative Names
DCTN1-p150 antibody; Gl antibody; CG9206 antibody; Dynactin subunit 1 antibody; 150 kDa dynein-associated polypeptide antibody; DAP-150 antibody; DP-150 antibody; Dynactin 1 subunit p150 antibody; Protein glued antibody
Raised in
Rabbit
Species Reactivity
Drosophila melanogaster (Fruit fly)
Immunogen
Recombinant Drosophila melanogaster (Fruit fly) DCTN1-p150 protein
Immunogen Species
Drosophila melanogaster (Fruit fly)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)
Usage
For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function
Required for the cytoplasmic dynein-driven retrograde movement of vesicles and organelles along microtubules. Dynein-dynactin interaction is a key component of the mechanism of axonal transport of vesicles and organelles.
Gene References into Functions
  1. Arfaptin physically associates with Glued and other dynactin complex components in the nervous system of both flies and mice and colocalizes with Glued at the Golgi in motor neurons. PMID: 23596322
  2. It uncovered an important requirement for Lis1 in promoting the recruitment of dynein and its accessory complex dynactin to RNA localization complexes. PMID: 23918939
  3. multiple independent disruptions of Dynactin function cause a relocation of the photoreceptor nucleus toward the brain PMID: 15329347
  4. Microtubule binding depends on the N-terminal domain of p150[glued]. PMID: 17325206
  5. show that this cell polarity regulator interacts with Glued during central synapse formation. PMID: 19948010

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Subcellular Location
Cytoplasm. Cytoplasm, cytoskeleton.
Protein Families
Dynactin 150 kDa subunit family
Database Links

KEGG: dme:Dmel_CG9206

STRING: 7227.FBpp0075498

UniGene: Dm.12980

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