Ddc Antibody

Code CSB-PA006583XA01DLU
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Product Details

Full Product Name
Rabbit anti-Drosophila melanogaster (Fruit fly) Ddc Polyclonal antibody
Uniprot No.
Target Names
Ddc
Alternative Names
Ddc antibody; CG10697Aromatic-L-amino-acid decarboxylase antibody; AADC antibody; EC 4.1.1.28 antibody; DOPA decarboxylase antibody; DDC antibody
Raised in
Rabbit
Species Reactivity
Drosophila melanogaster (Fruit fly)
Immunogen
Recombinant Drosophila melanogaster (Fruit fly) Ddc protein
Immunogen Species
Drosophila melanogaster (Fruit fly)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine. Variation in the synthesis of bioamines may be a factor contributing to natural variation in life span.
Gene References into Functions
  1. lowered expression of Atg6 or Pi3K59F in Ddc-Gal4-expressing neurons results in decreased longevity and associated age-dependent loss of locomotor ability. Inhibition of Atg6 or Pi3K59F together with overexpression of the sole pro-survival Bcl-2 Drosophila homolog Buffy in Ddc-Gal4-expressing neurons resulted in further decrease in the survival PMID: 27813607
  2. epidermal Ddc induction at pupariation is under the control of an extended genomic region that contains both positive and negative regulatory elements PMID: 12175493
  3. Broad-Complex protein is required for Ddc activation at eclosion in Drosophila PMID: 12464428
  4. evidence for a wound response pathway that senses aseptic breaks in the barrier epidermis of Drosophila embryos; a minimal 472-bp Ddc wound response enhancer requires a Grh protein binding site and the function of the grh gene PMID: 15831751
  5. The Ddc locus exhibits a complicated pattern of variation apparently due to several evolutionary forces. PMID: 17968140
  6. The involvement of DDC in a new pathway involved in Drosophila immunity increases the levels of dopamine, which is metabolized to produce reactive quinones that exert an antimicrobial effect on invading bacteria. PMID: 18519585

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Protein Families
Group II decarboxylase family
Tissue Specificity
Hypoderm isoform is expressed only in hypodermal epithelium and the CNS isoform only in central nervous system.
Database Links
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