bel Antibody

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Code	CSB-PA893283XA01DLU
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Target Background

Product Details

Full Product Name

Rabbit anti-Drosophila melanogaster (Fruit fly) bel Polyclonal antibody

Uniprot No.

Q9VHP0

Target Names

bel

Alternative Names

bel antibody; CG9748ATP-dependent RNA helicase bel antibody; EC 3.6.4.13 antibody; Protein belle antibody

Raised in

Rabbit

Species Reactivity

Drosophila melanogaster (Fruit fly)

Immunogen

Recombinant Drosophila melanogaster (Fruit fly) bel protein

Immunogen Species

Drosophila melanogaster (Fruit fly)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function

ATP-dependent RNA helicase that is essential and required for cellular function, larval growth, and for male and female fertility. Also required for RNA interference (RNAi), double-stranded RNA induces potent and specific gene silencing, by acting downstream of dsRNA internalization. RNAi is mediated by the RNA-induced silencing complex (RISC), a sequence-specific, multicomponent nuclease that destroys or silences messenger RNAs homologous to the silencing trigger.

Gene References into Functions

Bel is required for nos mRNA translational repression. PMID: 28701521
DDX3/Belle Exerts Its Function Outside of the Wnt/Wingless Signaling Pathway PMID: 28030561
show that genetic inhibition of Bel function leads to de novo generation of piRNAs from the transgene region inserted in the genome, suggesting a potential piRNA-dependent mechanism that may mediate transgene silencing as Bel function is inhibited PMID: 26900887
Results suggest that a role of RNA helicase Belle in germline stem cells (GSCs) and maintenance and germline stem cells (GSCs)regulation of early germ cell divisions. PMID: 26876306
findings show that the belle (bel) mRNA is translationally repressed by the d4EHP protein in the Drosophila ovary. Consistent with this regulation, d4EHP overexpression in the ovary phenocopies the bel mutant. PMID: 21788736
DEAD-box RNA helicase Belle and the RNA interference pathway promote mitotic chromosome segregation. PMID: 21730191
Belle might be functioning in the microRNA pathway in follicle cells. PMID: 21447549
Inactivation of bel renders cells less sensitive to several anti-proliferative signals inducing G1 arrest. PMID: 20160476

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Subcellular Location

Cytoplasm. Note=In nurse cells, follicle cells, and within the oocyte. Vas and bel colocalize in the perinuclear region of nurse cells.

Protein Families

DEAD box helicase family, DDX3/DED1 subfamily

Tissue Specificity

Vas and bel colocalize in nuage (perinuclear, electron-dense granules in germline cells) and at the oocyte posterior during oogenesis.

Database Links

KEGG: dme:Dmel_CG9748

STRING: 7227.FBpp0081374

UniGene: Dm.7823

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bel Antibody

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Target Background