pfpI Antibody

Code CSB-PA690404XA01FHW
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Product Details

Full Product Name
Rabbit anti-Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1) pfpI Polyclonal antibody
Uniprot No.
Target Names
pfpI
Alternative Names
pfpI antibody; PF1719 antibody; Deglycase PfpI antibody; EC 3.5.1.124 antibody; Intracellular protease I antibody; EC 3.4.22.- antibody
Raised in
Rabbit
Species Reactivity
Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Immunogen
Recombinant Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1) pfpI protein
Immunogen Species
Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Deglycase that catalyzes the deglycation of the Maillard adducts formed between amino groups of proteins and reactive carbonyl groups of glyoxals (Probable). Thus, functions as a protein deglycase that repairs methylglyoxal- and glyoxal-glycated proteins, and releases repaired proteins and lactate or glycolate, respectively. Deglycates cysteine, arginine and lysine residues in proteins, and thus reactivates these proteins by reversing glycation by glyoxals. Thus, was shown to afford full protection against glycation of thioredoxin by glyoxal. Acts on early glycation intermediates (hemithioacetals and aminocarbinols), preventing the formation of advanced glycation endproducts (AGE) that cause irreversible damage. Prevents acrylamide formation in asparagine/glyoxal and asparagine/sugar mixtures, likely by degrading asparagine/glyoxal Maillard adducts formed at high temperatures. Also displays proteolytic activity. Cleaves at the carboxyl side of both basic and hydrophobic residues in the P1 position, indicating trypsin- and chymotrypsin-like specificities.
Subcellular Location
Cytoplasm.
Protein Families
Peptidase C56 family
Database Links

KEGG: pfu:PF1719

STRING: 186497.PF1719

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