DH12B Antibody

Code CSB-PA764830XA01DIL
Product Type Polyclonal Antibody
Uniprot No. Q6QA33
Delivery Make-to-order
Protocols ELISA Protocol
Immunogen Recombinant Danio rerio (Zebrafish) (Brachydanio rerio) DH12B protein
Raised in Rabbit
Species Reactivity Danio rerio (Zebrafish) (Brachydanio rerio)
Tested Applications ELISA, WB (ensure identification of antigen)
Form Liquid
Conjugate Non-conjugated
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method Protein A/G
Isotype IgG
Clonality Polyclonal
Alias Very-long-chain 3-oxoacyl-CoA reductase-B (EC (17-beta-hydroxysteroid dehydrogenase 12-B) (17-beta-HSD 12-B) (zf3.3) (zfHSD17B12B) (3-ketoacyl-CoA reductase) (KAR) (Estradiol 17-beta-dehydrogenase 12-B) (EC hsd17b12b zgc:73289
Immunogen Species Danio rerio (Zebrafish) (Brachydanio rerio)
Gene Names hsd17b12b
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Catalyzes the second of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme has a 3-ketoacyl-CoA reductase activity, reducing 3-ketoacyl-CoA to 3-hydroxyacyl-CoA, within each cycle of fatty acid elongation. Thereby, it may participate in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May also catalyze the transformation of estrone (E1) into estradiol (E2) and play a role in estrogen formation.
Subcellular Location Endoplasmic reticulum membrane, Multi-pass membrane protein
Protein Families Short-chain dehydrogenases/reductases (SDR) family, 17-beta-HSD 3 subfamily
Database Links

KEGG: dre:322626

STRING: 7955.ENSDARP00000089612

UniGene: Dr.20571

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