Product Details

Full Product Name

Rabbit anti-Drosophila melanogaster (Fruit fly) Diap2 Polyclonal antibody

Uniprot No.

Q24307

Target Names

Diap2

Alternative Names

Diap2 antibody; DIHA antibody; Iap2 antibody; Ilp antibody; CG8293Death-associated inhibitor of apoptosis 2 antibody; Apoptosis 2 inhibitor antibody; IAP homolog A antibody; IAP-like protein antibody; ILP antibody; dILP antibody; Inhibitor of apoptosis 2 antibody

Raised in

Rabbit

Species Reactivity

Drosophila melanogaster (Fruit fly)

Immunogen

Recombinant Drosophila melanogaster (Fruit fly) Diap2 protein

Immunogen Species

Drosophila melanogaster (Fruit fly)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

Target Background

Function

Required for activation of NF-kappaB transcription factors in the immune deficiency (Imd) signaling cascade which is essential for innate immune responses upon infection by Gram-negative bacteria. Promotes cytoplasmic cleavage of Rel and its translocation to the nucleus where it drives expression of antimicrobial peptides. Binds, polyubiquitinates and activates Dredd which is required for Rel-mediated induction of antimicrobial peptides. Anti-apoptotic protein which binds, ubiquitinates and inactivates the effector caspase Drice. Suppresses rpr and hid-dependent cell death in the eye. However, has also been shown to have little, if any, role in the regulation of the canonical caspase-dependent apoptosis pathway. Plays a role in regulating the expression of ion channels.

Gene References into Functions

cleaved protein retains the ability to interact with immune deficiency pathway signal transduction PMID: 25968339
promotes growh regulation; expression in neuroendocrine cells is nutrient-dependent PMID: 12176357
DIAP1 ensures cell viability by directly inhibiting caspases. PMID: 14657035
role in inhibiting DrICE PMID: 15107838
precise timing of larval tissue cell death during metamorphosis is achieved through a steroid-triggered shift in the balance between the Drosophila inhibitor of apoptosis 1 and the rpr and hid death activators PMID: 15150408
Inhibitor of apoptosis 2 and TAK1-binding protein are components of the Imd pathway, which controls antimicrobial peptide expression in Drosophila. PMID: 16163390
Results identify DIAP2 as an essential component of the Imd signaling cascade, protecting the organism from infiltrating microbes. PMID: 16894030
diap2 may identify a point of convergence between apoptosis and immune signaling pathways PMID: 17068333
Required to sustain antimicrobial peptide gene expression; inactivation results in impaired microbial resistance. PMID: 17343912
Because DIAP2 efficiently interacts with drICE, our data suggest that DIAP2 controls drICE in its apoptotic and nonapoptotic roles. PMID: 18166655

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Subcellular Location

Nucleus. Cytoplasm.

Protein Families

IAP family

Tissue Specificity

Expressed in both principal and stellar cells of the Malphigian tubules.

Database Links

KEGG: dme:Dmel_CG8293

STRING: 7227.FBpp0086432

UniGene: Dm.7173

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Diap2 Antibody

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