dimm Antibody

Code CSB-PA469628XA01DLU
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Product Details

Full Product Name
Rabbit anti-Drosophila melanogaster (Fruit fly) dimm Polyclonal antibody
Uniprot No.
Target Names
dimm
Alternative Names
dimm antibody; CG8667Protein dimmed antibody
Raised in
Rabbit
Species Reactivity
Drosophila melanogaster (Fruit fly)
Immunogen
Recombinant Drosophila melanogaster (Fruit fly) dimm protein
Immunogen Species
Drosophila melanogaster (Fruit fly)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Transcription factor that regulates neurosecretory (NS) cell function and neuroendocrine cell fate. Acts as a master regulator of common NS functions such as Phm expression and neuropeptide production. Plays a role as a regulator of peptide-containing large dense-core vesicle (LDCV) production and peptidergic cell differentiation. Controls transcription of FMRFamide in Tv neuronal cells and Fur1 in Ap-let cells (Tvb and dorsal apterous cells). Also required for up-regulation of Phm in Tv and Ap-let cells, and expression of three neuropeptide genes, Ms, FMRFamide and Lk. Influences both regulated and constitutive secretory activity in neuroendocrine cells at embryonic and postembryonic level. Loss of function studies show reduced cellular levels of various neuropeptides and neuropeptide biosynthetic enzymes.
Gene References into Functions
  1. DIMM prescribes the scale of secretory activity in neuroendocrine neurons, by a systematic control of both proximal and distal points in the regulated secretory pathway. PMID: 25634895
  2. We also show that dInR expression in neuroendocrine cells can be altered by up or down-regulation of Dimm. PMID: 24385933
  3. Loss of SSDP, a key regulatory component of CHIP/LDB transcription complexes, alters transcription of a large group of genes. PMID: 20730086
  4. Nonpeptidergic neurons normally fail to accumulate ectopic neuropeptides. They will do so when they are also forced to express ectopic DIMM. PMID: 20045330
  5. The roles of crc and dimmed genes on the expression of diverse hormones in D. melanogaster and reported. PMID: 16651547
  6. DIMM is a master regulator of a peptidergic cell fate in Drosophila and provides a detailed transcriptional mechanism of DIMM action on a defined target gene PMID: 17967878
  7. DIMMED has a special role in the development and maintenance of neurosecretory cell fate in Drosophila as a dedicated pro-secretory factor. PMID: 19135054

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Subcellular Location
Cytoplasm.
Tissue Specificity
Detected in the developing nervous system in the bilateral domains in the cephalic region that later on forms part of the ring gland. Concomitantly expressed in the larval central nervous system (CNS), including the dorsal chain neurons as well as several
Database Links

KEGG: dme:Dmel_CG8667

STRING: 7227.FBpp0305546

UniGene: Dm.23895

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