djr-1.1 Antibody

Code CSB-PA942776XA01CXY
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Product Details

Full Product Name
Rabbit anti-Caenorhabditis elegans djr-1.1 Polyclonal antibody
Uniprot No.
Target Names
djr-1.1
Alternative Names
djr-1.1 antibody; B0432.2Glutathione-independent glyoxalase DJR-1.1 antibody; EC 4.2.1.130 antibody; Protein DJ-1 homolog 1 antibody
Raised in
Rabbit
Species Reactivity
Caenorhabditis elegans
Immunogen
Recombinant Caenorhabditis elegans djr-1.1 protein
Immunogen Species
Caenorhabditis elegans
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Catalyzes the conversion of methylglyoxal (MG) or glyoxal (GO) to D-lactate or glycolic acid respectively in a single glutathione (GSH)-independent step. May play a role in detoxifying endogenously produced glyoxals. Involved in protection against glyoxal-induced cell death.
Gene References into Functions
  1. The pdr1 and djr1.1 mutants showed enhanced Mn accumulation and oxidative stress that was reduced by alpha-synuclein. PMID: 24452053
  2. Lacking of DJR-1.1 expression protected Caenorhabditis elegans from glyoxal-induced death. PMID: 22523093
  3. Thus, PD-associated DJ-1 contributes to regulation of innate immunity. PMID: 20376509
  4. PD-related genetic modifications of alpha-synuclein, parkin, and DJ-1 disrupt the mitochondrial function in C. elegans [DJ-1 is B0432.2] PMID: 16239214
Subcellular Location
Cytoplasm. Nucleus.
Protein Families
Peptidase C56 family
Tissue Specificity
Expressed exclusively in the intestine.
Database Links

KEGG: cel:CELE_B0432.2

STRING: 6239.B0432.2.2

UniGene: Cel.16048

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